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The purpose of this study is to compare if a new noninvasive ventilation mode (NIV NAVA) is better in noninvasive ventilation of premature infants than currently used Nasal Continuous Airway Pressure (ncpap), and if NIV NAVA gives real benefits for patients or not.
The investigators study hypothesis is that with NIV NAVA the invasive ventilation is more synchronous with patient, which will lead to a decrease in need of inspired oxygen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NIV NAVA | Active Comparator | Noninvasive ventilation in this group is practiced with NIV NAVA |
|
| ncpap | Active Comparator | Patients randomized to this arm will receive noninvasive ventilation with continuous nasal CPAP as routinely in neonatal intensive care unit. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NIV NAVA | Device | Non invasive ventilation with neurally adjusted ventilatory assist |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of inspired oxygen supply | Participants will be followed for the duration of hospital stay, an expected average of 3 weeks | 30minutes- 3weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of noninvasive ventilation | Participants will be followed for the duration of hospital stay, an expected average of 3 weeks | 30 minutes - 3 weeks |
| Fraction of inspired oxygen | Participants will be followed for the duration of hospital stay, an expected average of 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oulu University hospital | Oulu | 90230 | Finland |
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| Nasal continuous positive airway pressure |
| Device |
Noninvasive respiratory support with continuous positive airway pressure |
|
| 0, 1, 3 and 6hours, after which every 6 hours |
| Blood gas analyses | Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. | 3 weeks |
| Duration of parenteral nutrition | Participants will be followed for the duration of hospital stay, an expected average of 3 weeks | 3 weeks |
| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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| ID | Term |
|---|---|
| D045422 | Continuous Positive Airway Pressure |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
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