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The purpose of this study is to determine whether iloperidone is effective in the treatment of Schizophrenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Risperidone | Active Comparator |
| |
| iloperidone | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| iloperidone | Drug | Iloperidone is being development as a treatment of schizophrenia. This trial will verify the safety and efficacy of iloperidone in patients with schizophrenia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Positive and Negative Symptom Scale(PANSS)-Total Score | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Effective percentage(PANSS score reduce rate≥50%) | 6 weeks | |
| Change in scores from baseline to end point assessment on the PANSS Positive subscale (PANSS-P) | 6 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sixth Hospital of Peking University | Beijing | Beijing Municipality | 100191 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16172203 | Background | Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005 Sep 22;353(12):1209-23. doi: 10.1056/NEJMoa051688. Epub 2005 Sep 19. |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| C081732 | iloperidone |
| D018967 | Risperidone |
| ID | Term |
|---|---|
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Risperidone | Drug | Risperidone is used for the treatment of schizophrenia.Risperidone is unique among most other atypicals in that it has high affinity for the D2 receptor whereas most other atypicals have 'loose binding' of the D2 receptor. It has actions at several 5-HT (serotonin) receptor subtypes. |
|
| Change in scores from baseline to end point assessment on the PANSS Negative subscale (PANSS-N) |
| 6 weeks |
| Change in scores from baseline to end point assessment on the PANSS General Psychopathology subscale(PANSS-GP) | 6 weeks |