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| Name | Class |
|---|---|
| New York State Department of Health | OTHER_GOV |
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A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
Cognitive changes in the elderly are common after surgery. It is not known if minimally invasive or laparoscopic surgery can prevent these changes. A study will be conducted on patients scheduled to have abdominal surgery. The patients will have cognitive evaluations before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. The results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic colon surgery | Patients over age 65 having laparoscopic colon resection for colonic adenocarcinoma | ||
| Open colon surgery | Patients over age 65 having open colon resection for colonic adenocarcinoma |
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| Measure | Description | Time Frame |
|---|---|---|
| Confusion | Confusion assessed by questionaires and cognitive testing | 6 Months |
| Measure | Description | Time Frame |
|---|---|---|
| degree of inflammation | 5 separate blood draws | 6 Months |
| presence of electrolyte imbalance | 5 separate blood draws | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients newly diagnosed with colon adenocarcinoma will be contacted after being scheduled for surgery at New York Hospital Queens.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mitchell Chorost, MD | Contact | 718-670-1185 | mchorost@nyp.org | |
| Mitchell I Chorost, MD | Contact | 718-670-1185 | mchorost@nyp.org |
| Name | Affiliation | Role |
|---|---|---|
| Mitchell I Chorost, MD | New York Hospital Queens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New York Hospital Queens | Recruiting | Flushing | New York | 11355 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20610543 | Background | Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7. | |
| 7864702 | Background | Dyer CB, Ashton CM, Teasdale TA. Postoperative delirium. A review of 80 primary data-collection studies. Arch Intern Med. 1995 Mar 13;155(5):461-5. doi: 10.1001/archinte.155.5.461. |
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| ID | Term |
|---|---|
| D003221 | Confusion |
| D007249 | Inflammation |
| D000210 | Acute-Phase Reaction |
| D003693 | Delirium |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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Plasma samples stored up to 7 months then expired and discarded
| pituitary-thyroid axis disruption | 5 separate blood draws | 6 months |
| liver function tests | 5 separate blood draws | 6 months |
| nutritional status | 5 separate blood draws | 6 months |
| 19573218 | Background | Juliebo V, Bjoro K, Krogseth M, Skovlund E, Ranhoff AH, Wyller TB. Risk factors for preoperative and postoperative delirium in elderly patients with hip fracture. J Am Geriatr Soc. 2009 Aug;57(8):1354-61. doi: 10.1111/j.1532-5415.2009.02377.x. Epub 2009 Jul 2. |
| 20069607 | Background | Ansaloni L, Catena F, Chattat R, Fortuna D, Franceschi C, Mascitti P, Melotti RM. Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg. 2010 Feb;97(2):273-80. doi: 10.1002/bjs.6843. |
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| 8948560 | Background | Roach GW, Kanchuger M, Mangano CM, Newman M, Nussmeier N, Wolman R, Aggarwal A, Marschall K, Graham SH, Ley C. Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. N Engl J Med. 1996 Dec 19;335(25):1857-63. doi: 10.1056/NEJM199612193352501. |
| 5100723 | Background | Layne OL Jr, Yudofsky SC. Postoperative psychosis in cardiotomy patients. The role of organic and psychiatric factors. N Engl J Med. 1971 Mar 11;284(10):518-20. doi: 10.1056/NEJM197103112841003. No abstract available. |
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| 6498664 | Background | Schubert DS, Gabinet L, Hershey LA. Psychosis induced by sustained-release procainamide. Can Med Assoc J. 1984 Nov 15;131(10):1188, 1190. No abstract available. |
| 3337520 | Background | Trohman RG, Castellanos D, Castellanos A, Kessler KM. Amiodarone-induced delirium. Ann Intern Med. 1988 Jan;108(1):68-9. doi: 10.7326/0003-4819-108-1-68. No abstract available. |
| 1899553 | Background | Binder EF, Cayabyab L, Ritchie DJ, Birge SJ. Diltiazem-induced psychosis and a possible diltiazem-lithium interaction. Arch Intern Med. 1991 Feb;151(2):373-4. |
| 12832977 | Background | Bohner H, Hummel TC, Habel U, Miller C, Reinbott S, Yang Q, Gabriel A, Friedrichs R, Muller EE, Ohmann C, Sandmann W, Schneider F. Predicting delirium after vascular surgery: a model based on pre- and intraoperative data. Ann Surg. 2003 Jul;238(1):149-56. doi: 10.1097/01.sla.0000077920.38307.5f. |
| 17038078 | Background | Dasgupta M, Dumbrell AC. Preoperative risk assessment for delirium after noncardiac surgery: a systematic review. J Am Geriatr Soc. 2006 Oct;54(10):1578-89. doi: 10.1111/j.1532-5415.2006.00893.x. |
| 8264068 | Background | Marcantonio ER, Goldman L, Mangione CM, Ludwig LE, Muraca B, Haslauer CM, Donaldson MC, Whittemore AD, Sugarbaker DJ, Poss R, et al. A clinical prediction rule for delirium after elective noncardiac surgery. JAMA. 1994 Jan 12;271(2):134-9. |
| 18809895 | Background | Redelmeier DA, Thiruchelvam D, Daneman N. Delirium after elective surgery among elderly patients taking statins. CMAJ. 2008 Sep 23;179(7):645-52. doi: 10.1503/cmaj.080443. |
| 1752118 | Background | Vgontzas AN, Kales A, Bixler EO, Manfredi RL, Tyson KL. Effects of lovastatin and pravastatin on sleep efficiency and sleep stages. Clin Pharmacol Ther. 1991 Dec;50(6):730-7. doi: 10.1038/clpt.1991.213. |
| 5549939 | Background | Lewis WH. Iatrogenic psychotic depressive reaction in hypertensive patients. Am J Psychiatry. 1971 Apr;127(10):1416-7. doi: 10.1176/ajp.127.10.1416. No abstract available. |
| 17487768 | Background | Norkiene I, Ringaitiene D, Misiuriene I, Samalavicius R, Bubulis R, Baublys A, Uzdavinys G. Incidence and precipitating factors of delirium after coronary artery bypass grafting. Scand Cardiovasc J. 2007 Jun;41(3):180-5. doi: 10.1080/14017430701302490. |
| 11511942 | Background | Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y. Delirium in an intensive care unit: a study of risk factors. Intensive Care Med. 2001 Aug;27(8):1297-304. doi: 10.1007/s001340101017. |
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| 16135031 | Background | Briggs W, Ruppert D. Assessing the skill of yes/no predictions. Biometrics. 2005 Sep;61(3):799-807. doi: 10.1111/j.1541-0420.2005.00347.x. |
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| 1202204 | Background | Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available. |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |