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To compare postoperative pain, opioid consumption and chronic pain in patients undergoing to hernia repair surgery after receiving nitrous oxide or oxygen during the general anesthesia.
The study is prospective and double blind. In the clinic, patients undergoing inguinal hernia surgery that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nitrous oxide | Experimental | Subjects will receive General anesthesia with Nitrous Oxide. |
|
| Oxygen | Placebo Comparator | Subjects will receive General anesthesia with oxygen. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nitrous Oxide | Drug | Nitrous Oxide, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Nitrous oxide and chronic pain | The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in prevention of chronic pain. | 30 days post operative |
| Nitrous oxide and opioid consumption | The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in decrease in opioid consumption. | 4 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| smoking and post operative pain | The effect of active smoking to increase post operative acute pain. | 4 hours after surgery |
| smoking and chronic pain | The effect of active smoking and chronic pain |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alparslan Turan, M.D. | The Cleveland Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gulhane Military Medical Academy Hospital | Etlik | Ankara | 06018 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D010100 | Oxygen |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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| oxygen | Other | Subjects will receive General anesthesia: (Air, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg. |
|
| 30 days post operative |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D018011 | Chalcogens |
| D004602 | Elements |