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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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Focus of this study was to determine if bupropion was more effective for smoking cessation when used alone or combined with nicotine gum.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active bupropion-Active gum | Active Comparator | 150 mg bupropion twice daily + 4 mg nicotine gum as needed (up to 12 pcs/day) |
|
| Active bupropion-Placebo gum | Active Comparator | 150mg bupropion twice daily + placebo gum as needed (up to 12 pcs/day) |
|
| Placebo medication-Placebo gum | Active Comparator | Placebo bupropion, twice daily, plus placebo gum as needed (up to 12 pcs/day) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bupropion + nicotine gum | Drug | 150 mg bupropion twice daily plus 4 mg nicotine gum as needed (up to 12 pcs/day) |
|
| Measure | Description | Time Frame |
|---|---|---|
| 7-day point prevalence abstinence measured at 6 months | No smoking, not evan a puff, during the 7 days prior to the 6 month follow-up | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UW Center for Tobacco Research and Intervention | Madison | Wisconsin | 53711 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17763111 | Result | Piper ME, Federman EB, McCarthy DE, Bolt DM, Smith SS, Fiore MC, Baker TB. Efficacy of bupropion alone and in combination with nicotine gum. Nicotine Tob Res. 2007 Sep;9(9):947-54. doi: 10.1080/14622200701540820. | |
| 37230961 | Derived | Hajizadeh A, Howes S, Theodoulou A, Klemperer E, Hartmann-Boyce J, Livingstone-Banks J, Lindson N. Antidepressants for smoking cessation. Cochrane Database Syst Rev. 2023 May 24;5(5):CD000031. doi: 10.1002/14651858.CD000031.pub6. |
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| ID | Term |
|---|---|
| D014029 | Tobacco Use Disorder |
| D016540 | Smoking Cessation |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D015438 | Health Behavior |
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| ID | Term |
|---|---|
| D016642 | Bupropion |
| D000074164 | Nicotine Chewing Gum |
| ID | Term |
|---|---|
| D011427 | Propiophenones |
| D007659 | Ketones |
| D009930 | Organic Chemicals |
| D002638 | Chewing Gum |
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| Active bupropion-Placebo gum | Drug | 150mg bupropion twice daily plus placebo nicotine gum as needed (up to 12 pcs/day) |
|
| Placebo bupropion-Placebo gum | Drug | Placebo bupropion twice daily + placebo nicotine gum as needed (up to 12 pcs/day) |
|
| D001519 | Behavior |
| D053149 |
| Plant Gums |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D061485 | Tobacco Use Cessation Devices |
| D013812 | Therapeutics |
| D002182 | Candy |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |