Bupropion SR Plus Counseling for Smoking Cessation

A Randomized Controlled Clinical Trial of Bupropion SR and Individual Smoking Cessation Counseling

The purpose of this study was to determine if bupropion plus counseling was more effective than bupropion alone or counseling alone in helping smokers quit smoking.

Inclusion Criteria:

• Smoke 10 or more cigarettes per day
• Expired carbon monoxide (CO) level greater than 9 parts per million (ppm)
• Motivated to quit smoking (score of 3 on 4-point self-report scale)
• Willing to fulfill study requirements

Exclusion Criteria:

• Carbon monoxide breath test score below 9 ppm
• Serious psychopathology (bipolar disorder, psychosis)
• Center for Epidemiologic Studies Depression Scale CES-D)score over 16
• Contraindications for use of bupropion
• History of seizure disorder
• History of eating disorder
• Current heavy drinking
• Risk of pregnancy
• Current breastfeeding