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The purpose of this pilot study is whether Eye Movement Desensitization Reprocessing (EMDR), an approved psychotherapy in posttraumatic stress disorder, improves mood, functioning, quality of life, cognition and BDNF levels in subsyndromal bipolar patients with trauma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EMDR | Experimental |
| |
| TAU | No Intervention | Treatment as usual (TAU) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eye Movement Desensitization Reprocessing (EMDR) | Other | EMDR is an effective treatment in PTSD but has never been tested in bipolar traumatized patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome of this study is a statistically significant reduction in the YMRS and/or HDRS in the EMDR group compared with the TAU group. | Patients with subsydromal symptoms, objectified by the YMRS and HDRS, are included in the study. After randomization to EMDR or TAU, group differences in changes in the YMRS and HRDS are measured at visit after intervention (3 months) and at follow-up (6 months). The hypothesize is that the EMDR group will statistically improve in both affective scales when compared to the TAU group. | 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| The EMDR group improves statistically significant in trauma load when compared to TAU. | Secondary outcome measure includes changes in trauma scales (IES, CAPS)from baseline to 3 months and 6 months. | 3 months and 6 months |
| The EMDR group improves statistically significant in cognitive tests when compared to TAU. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Benedikt L Amann, MD | FIDMAG Germanes Hospitalà ries | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| FIDMAG | Barcelona | Barcelona | 08035 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17543031 | Background | Kauer-Sant'Anna M, Tramontina J, Andreazza AC, Cereser K, da Costa S, Santin A, Yatham LN, Kapczinski F. Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology. Bipolar Disord. 2007 Jun;9 Suppl 1:128-35. doi: 10.1111/j.1399-5618.2007.00478.x. | |
| 17636720 | Background | Bisson J, Andrew M. Psychological treatment of post-traumatic stress disorder (PTSD). Cochrane Database Syst Rev. 2007 Jul 18;(3):CD003388. doi: 10.1002/14651858.CD003388.pub3. |
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| ID | Term |
|---|---|
| D001714 | Bipolar Disorder |
| D013313 | Stress Disorders, Post-Traumatic |
| D014947 | Wounds and Injuries |
| ID | Term |
|---|---|
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
| D040921 | Stress Disorders, Traumatic |
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| ID | Term |
|---|---|
| D057169 | Eye Movement Desensitization Reprocessing |
| ID | Term |
|---|---|
| D003887 | Desensitization, Psychologic |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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Subjects underwent a neuropsychologcial battery to test various cognitive domains. |
| 3 months and 6 months |
| The EMDR group improves statistically significant in functioning when compared to TAU. | All subjects were evaluated with respect to their functioning using the FAST, a validated scale of functioning in bipolar disorder. | 3 months and 6 months |
| The EMDR group improves statistically significant in quality of life when compared to TAU. | Possible changes of Quality of life were tested in all subjects as well, using the SF-36. | 3 months and 6 months |
| Plasma levels of BDNF was statistically higher in the EMDR group after intervention when compared to TAU. | Levels of BDNF are lower in bipolar patients, and even lower when traumatized, when compared to the general population. We aimed to find higher levels of BDNF in the EMDR group. | 3 months and 6 months |
| D000068099 | Trauma and Stressor Related Disorders |