Research never begun and no subjects enrolled. Protocol term with IRB in Dec 2014

To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT

as above

Inclusion Criteria:

• Age 18 or older and able to sign consent (or surrogate)
• Receiving liver or combined liver-kidney transplant
• eGFR < or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease
• Pre-operative potassium of < or equal to 5.5 mEq/L

Exclusion Criteria:

• Pre-operative hemoglobin < or equal to 7 g/dL
• Pre-operative weight > or equal to 125 kig