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A novel computerised neuropsychological test battery for normal pressure hydrocephalus (NPH) has been developed. The aim is to provide the clinician with a free of charge, standardized tool, assessing the cognitive decline or improvements in the cognitive domains specific for NPH. Results from the battery indicate good reliability and validity for the computerized tests
Results from the computerised battery seems promising. However, ability for the battery to detect cognitive improvements after a shunt operation remains to be tested.
Study objectives
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| INPH-patients | Inclusion criteria Older than 60 years of age "Probable INPH" according to the NIH guidelines Planned shunt surgery based on a diagnosis of INPH. Exclusion criteria Known cause for hydrocephalus (i.e., secondary NPH). Medical condition preventing cognitive testing (e.g. deafness, blindness). Patients not considered for shunt operation. |
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| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychological outcome | INPH patients, who are shunt candidates, will complete a computerized battery at two occasions: (1) hospital admission (Baseline) at most 1 month prior to surgery, and (2) 4.5 ± 1.5 months after shunt operation (Post-Shunt). | 4.5 ± 1.5 months |
| Measure | Description | Time Frame |
|---|---|---|
| Mini mental state Examination | INPH patients, who are shunt candidates, at each center will complete the Mini Mental State Examination at: (1) hospital admission (Baseline) at most 1 month prior to surgery, and (2) 4.5 ± 1.5 months after shunt operation (Post-Shunt). | 4.5 ± 1.5 months |
| Feasibility |
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Inclusion Criteria:
"Probable INPH" according to the NIH guidelines
Planned shunt surgery based on a diagnosis of INPH.
Exclusion Criteria:
Patients not considered for shunt operation.
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Eighty INPH-patients. Consecutively included.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ålborg University Hospital | Not yet recruiting | Aalborg | 9100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30738407 | Derived | Behrens A, Elgh E, Leijon G, Kristensen B, Eklund A, Malm J. The Computerized General Neuropsychological INPH Test revealed improvement in idiopathic normal pressure hydrocephalus after shunt surgery. J Neurosurg. 2019 Feb 8;132(3):733-740. doi: 10.3171/2018.10.JNS18701. Print 2020 Mar 1. |
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| ID | Term |
|---|---|
| D006850 | Hydrocephalus, Normal Pressure |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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The number of patients who are able to complete individual subtests and the entire battery, will be monitored. |
| 4.5 ± 1.5 months |
| Baseline cognitive profile compared to healthy | The baseline cognitive profile of INPH-patients will be compared to healthy individuals (from previous study). |
| Linköping University Hospital | Not yet recruiting | Linköping | 581 85 | Sweden |
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| Umeå University | Recruiting | Umeå | 901 85 | Sweden |
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| Akademiska sjukhuset | Not yet recruiting | Uppsala | 751 85 | Sweden |
|
| D019965 |
| Neurocognitive Disorders |
| D001523 | Mental Disorders |