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| Name | Class |
|---|---|
| Merck Sharp & Dohme LLC | INDUSTRY |
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In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.
Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| General asthma population | People with asthma, aged 18 years and over, non smoker, all severities of disease, regardless of treatment, broad inclusion and few exclusion criteria. |
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| Measure | Description | Time Frame |
|---|---|---|
| Serum periostin level | This is a cross sectional study. Participants will be assessed and tests conducted at a single visit | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| skin prick test | 1 day | |
| Serum total IgE | 1 day | |
| Blood eosinophil count |
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Inclusion Criteria:
Exclusion Criteria:
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People with asthma, non smoker, aged 18 and over.
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| Name | Affiliation | Role |
|---|---|---|
| John A Haughney, MB ChB | NSHI Ltd | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NSHI Ltd | Dartford | Kent | DA1 5GA | United Kingdom |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D006967 | Hypersensitivity |
| D004194 | Disease |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| 1 day |
| Blood neutrophil count | 1 day |
| Blood CD4 cells that are positive for CRTh2 | 1 day |
| Blood eosinophils expressing CRTh2 | 1 day |
| Spirometry | 1 day |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D007154 | Immune System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |