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The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| severe knee OA who are indicated for total knee arthroplasty | the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dual energy x-ray absorptiometry | Radiation | before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in bone mineral density | Use dual energy x-ray absorptiometry to detect to BMD at the distal femur | before the surgery and after the sugery (6month ,12month) |
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Inclusion Criteria:
Exclusion Criteria:
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the patients who are indicated for total knee arthroplasty and are post menopausal women. The patients who had history of immune disease , fracture of the femur and end stage of renal disease will be excluded
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ching Chuan Jiang, professor | Contact | 23123456 | 65273 | ccj@ntu.edu.tw |
| Wei cheng Huang, resident | Contact | osteocheng@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| ching chuan Jiang, professor | National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National taiwan university hospital | Taipei | Taiwan | 100 | Taiwan |
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A 2X1X0.5cm bone fragment harvested during the chamfer cut of total knee arthroplasty
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D015502 | Absorptiometry, Photon |
| ID | Term |
|---|---|
| D011859 | Radiography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003720 | Densitometry |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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