Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The primary aim of this study is to compare, in a group of at-risk individuals, the role of three dietary patterns on indices of Cardiovascular Disease (CVD) risk: a) the recommended Korean pattern; b) the typical American diet, based on national dietary intake surveys; and c) the 2010 DGA diet pattern. A secondary aim will be to assess the effects of each diet on intestinal microbiota and on inflammatory biomarkers.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Korean Recommended Diet | Experimental | A dietary pattern that follows the recommendations by the Korean Rural Development Administration. |
|
| US Recommended Diet | Active Comparator | Diet based on recipes and menus developed by the USDA Dietary Guidelines for Americans intramural team. |
|
| Typical American Diet | Active Comparator | Diet based on data from the NHANES surveys, as summarized in the USDA report What We Eat in America. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Controlled Feeding Dietary Intervention | Other | All meals will be provided during each 4-week intervention period. Participants must consume all foods provided and must not consume any outside foods during each intervention period. |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular Disease Biomarkers | Plasma total cholesterol, HDL and LDL cholesterol, insulin, glucose, and serum triglycerides will be measured. | End of each 4-week diet period |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory Markers | Cytokine production will be analyzed by selecting representative pro-inflammatory cytokine genes (i.e. TNF-a, IL-12, IL-6, IFNg), anti-inflammatory genes (IL-10), and different signaling pathways (i.e. Mitogen activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor Kappa B (NF-KB). | End of each 4-week diet |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| USDA Beltsville Human Nutrition Research Center | Beltsville | Maryland | 20705 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26115560 | Derived | Schroeder N, Park YH, Kang MS, Kim Y, Ha GK, Kim HR, Yates AA, Caballero B. A randomized trial on the effects of 2010 Dietary Guidelines for Americans and Korean diet patterns on cardiovascular risk factors in overweight and obese adults. J Acad Nutr Diet. 2015 Jul;115(7):1083-92. doi: 10.1016/j.jand.2015.03.023. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Markers of appetite and food intake regulation | Plasma adiponectin, ghrelin, PYY and leptin will be measured. | End of each 4-week diet |
| Blood pressure | End of each 4-week diet |
| Urinary sodium excretion, potassium, urea nitrogen, phosphorus, and creatinine | End of each 4-week diet |
| Change in fecal microbiota | Fecal samples will be collected to study changes in bacterial abundance of commensal microorganisms such as Bifidobacterium spp., Lactobacillus spp., E.coli spp. and Bacteroides fragilis spp. | At baseline and after 4-weeks of each diet |
| Dietary Questionnaires | Participants will be asked to complete questionnaires regarding acceptability, satiety, and gastrointestinal symptoms. | At end of each 4-week diet |
| D009750 |
| Nutritional and Metabolic Diseases |