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Radiation synovectomy by intra-articular injection of beta-emitting radionuclides is considered a reliable and easy-to-perform therapy without harmful side-effects for the treatment of inflammatory joint disease in many countries.
The goal of this study is to demonstrate Yttrium-90 citrate colloid or Rhenium-186 sulfide synovectomy are appropriate therapeutic interventions in patients with persistent active synovitis of a joint (characterized by pain, tenderness, and effusion) which is resistant to systemic therapy and intra-articular corticosteroid injections.
The primary objective will be to assess the safety of an intra-articular administration of Yttrium-90 citrate colloid or Rhenium-186 sulfide.
The secondary objective will be to assess the efficacy on synovitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| radiosynoviorthesis with yttrium-90 or rhenium -186 | Other | Patients suffering from arthritis or chronic inflammatory joint disease. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiosynoviorthesis | Drug | Intraarticular administration from 111 to 222 Mbq yttrium-90 per joint |
|
| Measure | Description | Time Frame |
|---|---|---|
| safety | The safety profile will be assessed by the incidence of AEs. All the AEs will be described by system/organ class and preferred terms and overall sorted by frequency. | 3-4 days post -treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy | Efficacy outcomes will be the clinical response over 1 year post treatment ( at 3, 6 and 12 months):The comparison will be done with a confidence interval approach based on a Chi²-test for each of the above secondary criterion assessed at different times during the follow-up compared to the same criterion assessed at baseline. | Clinical response post treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Turcotte, MD | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alberta Children's Hospital | Calgary | Alberta | Canada | |||
| Lion's Gate Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38754957 | Derived | Desaulniers M, Paquette M, Dubreuil S, Senta H, Lavallee E, Thorne JC, Turcotte E. Safety and Efficacy of Radiosynoviorthesis: A Prospective Canadian Multicenter Study. J Nucl Med. 2024 Jul 1;65(7):1095-1100. doi: 10.2967/jnumed.123.267297. |
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| ID | Term |
|---|---|
| D001168 | Arthritis |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Vancouver |
| British Columbia |
| V7L 2L1 |
| Canada |
| Health Science Centre | Winnipeg | Manitoba | Canada |
| Southlake Regional Health Centre | Newmarket | Ontario | Canada |
| Centre de santé et services sociaux Pierre-Boucher, Hôpital Pierre-Boucher | Longueuil | Quebec | Canada |
| Centre hospitalier de l'Université de Montréal | Montreal | Quebec | Canada |
| Centre hospitalier universitaire de Sherbrooke | Sherbrooke | Quebec | J1H 5N4 | Canada |
| CHR Trois-Rivières | Trois-Rivières | Quebec | Canada |
| Centre Hospitalier Universitaire de Québec | Québec | Canada |