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This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.
This is a study of visual outcomes in retinal disease. It is an observational study of patients who have been seen in the retinal clinic, and involves a retrospective casenotes analysis to identify patients who have suffered visual loss and the reason for that visual loss. These data will be analysed to enable the identification of factors that predict visual loss in patients who present earlier in the course of their disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with ocular inflammation | Patients with ocular inflammation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immunosuppressive Agents | Drug | Treatment with systemic corticosteroids and/or immunosuppressive agents Treatment with local corticosteroids and other drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity at 5 years | Best-corrected visual acuity at 5 years | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity at 10 years | Best corrected visual acuity at 10 years | 10 years |
| Source of referral | Categorised as A&E/GP referral/Optician referral/Tertiary referral |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with ocular inflammation
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| Name | Affiliation | Role |
|---|---|---|
| Simon RJ Taylor, PhD FRCOphth | Royal Surrey County Hospital NHS Foundation Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Moorfields Eye Hospital | London | London | EC1V 2PD | United Kingdom | ||
| Royal Surrey County Hospital |
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| ID | Term |
|---|---|
| D014605 | Uveitis |
| D015423 | Scleritis |
| ID | Term |
|---|---|
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
| D015422 | Scleral Diseases |
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| ID | Term |
|---|---|
| D007166 | Immunosuppressive Agents |
| D011239 | Prednisolone |
| D001379 | Azathioprine |
| D008727 | Methotrexate |
| D009173 | Mycophenolic Acid |
| D016572 | Cyclosporine |
| D000069285 | Infliximab |
| D000068879 | Adalimumab |
| D000068800 | Etanercept |
| D000069283 | Rituximab |
| ID | Term |
|---|---|
| D007155 | Immunologic Factors |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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|
| Baseline |
| Laterality | Categorised as: Right eye/Left eye/Bilateral | Baseline |
| Anatomical diagnosis | Cateogorised as: Acute anterior uveitis / Chronic anterior uveitis / Fuchs heterochromic cyclitis / Intermediate uveitis / Pars planitis / Posterior Uveitis / Panuveitis / Episcleritis / Scleritis | Baseline |
| Aetiological diagnosis | Diagnosed as: Viral / Bacterial / Fungal / Parasitic / Inflammatory / Malignant | Baseline |
| Associated systemic disease | Any associated systemic disease, e.g. HLA-B27 associated disease, Behcet's disease, multiple sclerosis, Vogt-Koyanagi-Harada syndrome, rheumatoid arthritis, collagen vascular disease, tuberculosis, granulomatosis with polyangiitis | Baseline |
| Complications of disease and causes of visual loss at 5 years | Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other | 5 years |
| Complications of disease and causes of visual loss at 10 years | Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other | 10 years |
| Complications of disease and causes of visual loss | Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other | Up to 10 years |
| Treatment measures employed | Categorised into: Topical treatment / periocular steroid / intraocular steroid / intraocular other agent / Glaucoma treatment / systemic immunosuppressive agents | Up to 10 years |
| Complications of disease and treatment | Categorised into:
| Up to 10 years |
| Surgical procedures | List and dates of any intraocular surgery performed during the study | Up to 10 years |
| Burden of disease - appointments | Number of outpatient appointments over the course of the study | Up to 10 years |
| Burden of disease - outpatient procedures | Number of outpatient procedures over the course of the study | Up to 10 years |
| Burden of disease - inpatient procedures | Number of inpatient procedures over the course of the study | Up to 10 years |
| Blind registration | Year of any registration as partially sighted or blind | Up to 10 years |
| Guildford |
| UK |
| GU2 7XX |
| United Kingdom |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013872 | Thionucleosides |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D015122 | Mercaptopurine |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D002208 | Caproates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D003524 | Cyclosporins |
| D010456 | Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D061067 | Antibodies, Monoclonal, Humanized |
| D007141 | Immunoglobulin Fc Fragments |
| D007128 | Immunoglobulin Fragments |
| D010446 | Peptide Fragments |
| D007127 | Immunoglobulin Constant Regions |
| D018124 | Receptors, Tumor Necrosis Factor |
| D018121 | Receptors, Cytokine |
| D011971 | Receptors, Immunologic |
| D011956 | Receptors, Cell Surface |
| D008565 | Membrane Proteins |
| D058846 | Antibodies, Monoclonal, Murine-Derived |