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The aim of our study is to determine the time to resolution of individual acne lesions using a popular handheld heat based device in comparison to no treatment and to standard topical therapy with benzoyl peroxide in order to determine its effectiveness in the spot treatment of acne vulgaris. Patient satisfaction and potential side effects will be examined as well.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heat based treatment/no treatment | Placebo Comparator | Split face treatment with handheld acne heat based device and no treatment |
|
| Heat based treatment/benzoyl peroxide | Active Comparator | Split face treatment with handheld acne heat based device and benzoyl peroxide 4% |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Split face: handheld acne heat based device (Zeno Hot Spot) and no treatment | Device | Subjects will apply the actual device to every inflammatory acne facial lesion on one half of the face and no treatment to every inflammatory acne lesion on the other half of the face at 6 hour intervals for a total of 3 treatments. Follow up will occur daily over a 5 day period. |
| Measure | Description | Time Frame |
|---|---|---|
| Time to resolution of individual acne lesions | Subjects will be photographed daily and the progression of individual acne lesions will be followed. Time to resolution of each lesion will be determined for the various treatment groups. | 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Device tolerability | Device tolerability will be assessed daily by asking the subject about adverse effects experienced from the treatments. At the end of 5 days, subjects will be asked to rate the various treatments based on ease of use and how much the side effects bothered him or her. | 5 days |
| Split-face investigator's static global assessment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shannon Humphrey, MD, FRCPC | UBC Department of Dermatology and Skin Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Skin Care Centre | Vancouver | British Columbia | V5Z4E8 | Canada |
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| ID | Term |
|---|---|
| D000152 | Acne Vulgaris |
| ID | Term |
|---|---|
| D017486 | Acneiform Eruptions |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012625 | Sebaceous Gland Diseases |
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|
| Split face: handheld acne heat based device, Zeno Hot Spot, and topical benzoyl peroxide 4% | Device | Subjects will apply the actual device to every inflammatory acne facial lesion on one half of the face at 6 hour intervals for a total of 3 treatments. Subjects will apply benzoyl peroxide to the other half of the face daily for 5 days. |
|
Split-face investigator's static global assessments will be conduced daily on subjects for 5 days. |
| 5 days |
| Acne lesion counts | Lesion counts will be performed daily for 5 days. | 5 days |