Efficiency of TISSEEL for Sleeve Gastrectomy Complications

Randomized Prospective Clinical Study Evaluating the Usefulness of Fibrin Glue (TISSEEL® KIT) to Prevent Gastric Fistula, Intra Abdominal Haemorrhage and Intra Abdominal Loco Regional Collections After Laparoscopic Sleeve Gastrectomy

Laparoscopic Sleeve Gastrectomy has emerged over the last 20 years as a treatment of choice in the surgical management of patients with morbid obesity. However, this restrictive procedure is accompanied by outcomes such as gastric fistula (5%), postoperative hemorrhage (1%) and intra-abdominal loco regional collections (1%). At present, there is no sufficiently reliable technique to prevent these complications.

The hypothesis is the following : the use of fibrin glue (Tissucol ®) during Laparoscopic Sleeve Gastrectomy would reduce the incidence of complications (gastric fistula, intra-abdominal hemorrhage and intra-abdominal locoregional collection).

The aim is to investigate whether the use of fibrin glue (Tissucol®) during Laparoscopic Sleeve Gastrectomy reduces the incidence of postoperative complications (gastric fistula, intra-abdominal hemorrhage and intra-abdominal locoregional collection)

Inclusion Criteria:

• Obesity requiring bariatric surgery (Laparoscopic Sleeve Gastrectomy) according to the Haute Autorité de Santé
• Patients younger than 60 years old
• BMI ≤ 60 kg/m2
• Surgery accepted by an Obesity-related specific committee
• Patient with social protection

Exclusion Criteria:

• Previous bariatric or gastric surgery
• BMI > 60 kg/m2
• Under 18 years old
• Allergy to Tissucol®
• peroperative fistula
• Consent not signed
• Incapable of giving his opinion
• Pregnancy or breast-feeding
• Contraindication to surgery
• ASA classification IV