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The purpose of this study is to compare the efficacy of autologous enriched bone marrow cell implantation combined with core decompression to single core decompression for the treatment of avascular necrosis of femoral head.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group:core decompression | Sham Comparator | single core decompression |
|
| Treatment group: BMCs+core decompression | Active Comparator | Enriched bone marrow cells combined with core decompression |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| core decompression | Procedure | minimal surgical invention to drill a core to the femoral head to release pressure |
|
| Measure | Description | Time Frame |
|---|---|---|
| change of Visual Analogue Scale | Change from baseline in 24 months | before invention and 24 months after invention |
| change of lequensne algofunctional index | change from baseline in 24 months | before invention and 24 months after invention |
| change of WOMAC index | change from baseline in 24 months | before invention and 24 months after invention |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32678055 | Derived | Li M, Ma Y, Fu G, Zhang R, Li Q, Deng Z, Zheng M, Zheng Q. 10-year follow-up results of the prospective, double-blinded, randomized, controlled study on autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of the femoral head. Stem Cell Res Ther. 2020 Jul 16;11(1):287. doi: 10.1186/s13287-020-01810-8. | |
| 25315149 |
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| ID | Term |
|---|---|
| D005271 | Femur Head Necrosis |
| ID | Term |
|---|---|
| D010020 | Osteonecrosis |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D009336 | Necrosis |
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| Enriched BMCs implantation combined with core decompression | Procedure | Patients are subjected to bone marrow aspiration from the anterior iliac crest. Mononuclear cells are enriched from patients' bone marrow by centrifuge, which are grafted with autologous cortical bone and implanted to the necrotic zone of the femoral head. |
|
| Ma Y, Wang T, Liao J, Gu H, Lin X, Jiang Q, Bulsara MK, Zheng M, Zheng Q. Efficacy of autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of femoral head: a prospective, double-blinded, randomized, controlled study. Stem Cell Res Ther. 2014 Oct 14;5(5):115. doi: 10.1186/scrt505. |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |