Effect of Saccharomyces Cerevisiae on the Symptoms of Irritable Bowel Syndrome

Effect of S.Cerevisiae vs Placebo on the Improvement of Gastrointestinal Disorders,Especially During Irritable Bowel Syndrome. Randomized, Double-blind Study

The main purpose of this study is the effect of the probiotic yeast Saccharomyces cerevisiae CNCM I-3856 on abdominal pain or intestinal discomfort in patients presenting with the irritable bowel syndrome (IBS)

Inclusion criteria:

• IBS subject meeting the Rome III criteria , with a discomfort or pain present more than 1 day per week in whom organic causes of their symptoms have been excluded
• IBS-C with less than 3 complete spontaneous bowel movements/week
• IBS-D with at least 2 or more days/week one stool which has consistency of type 6 or 7 Bristol stool score
• Subject able of and willing to comply with the protocol and to give their written informed consents

Exclusion criteria:

• History of chronic gastrointestinal disorders
• History of lactose intolerance
• History of gluten intolerance
• Treatment able to influence IBS, modifying intestinal sensitivity and motility (antidepressants,opioid, narcotic analgesics)
• Eating disorders
• Pregnancy in progress