Inclusion Criteria:
- > 1 year history of migraine with or without aura as defined by International Headache Society (IHS) criteria 1.1 and/or 1.2
- Migraines typically last between 4 to 72 hours, if untreated
- ≥ 2 and ≤ 8 moderate or severe migraine attacks per month in each of
the two months prior to screening
- Male, female who is not of reproductive potential, or female of
reproductive potential with a screening serum β-human chorionic gonadotropin (β-hCG) level consistent with a not-pregnant state, and who agrees to use acceptable contraception
Exclusion Criteria:
- Pregnant or breast-feeding, or is a female expecting to conceive within the projected duration of study participation
- Participant has difficulty distinguishing his/her migraine attacks from tension-type headaches
- History of predominantly mild migraine attacks or migraines that usually
resolve spontaneously in less than two hours
- More than 15 headache-days per month or has taken medication for acute headache on more than 10 days per month in any of the three months prior to screening
- Basilar-type or hemiplegic migraine headache
- > 50 years old at age of migraine onset
- Taking migraine prophylactic medication where the prescribed daily dose
has changed during the 3 months prior to screening and will not be changed
during the study
- Taking a proton pump inhibitor (PPI) or a histamine receptor 2 (H2) blocker on a daily or near daily basis (> 3 days per week)
- Taking the following medications from 1 month prior to screening through study period: potent cytochrome P450 (CYP) 3A4 inhibitors (e.g., cyclosporine, itraconazole, ketoconazole, fluconazole, erythromycin, clarithromycin, nefazodone, telithromycin, cimetidine, quinine, diltiazem, verapamil, and human immunodeficiency virus [HIV] protease inhibitors), moderate or marked CYP3A4 inducers (e.g., rifampicin, rifabutin, barbiturates [e.g., phenobarbital and primidone], systemic glucocorticoids, nevirapine, efavirenz, pioglitazone, carbamazepine, phenytoin, and St. Johns wort), or drugs with narrow therapeutic margins and potential for drug interactions in the CYP2C family (e.g., warfarin)
- Participant is unable to refrain from consumption of grapefruit or grapefruit juice during study
- History of hypersensitivity to, or has experienced a serious adverse event
in response to 3 or more classes of drugs (prescription and over-the-counter)
- Clinical or laboratory evidence of uncontrolled diabetes, human immunodeficiency virus (HIV) disease, or significant pulmonary, renal, hepatic, endocrine, or other systemic disease
- Other confounding pain syndromes, psychiatric conditions such as uncontrolled major depression, dementia or significant neurological disorders other than migraine. Patients who are currently being treated with non-prohibited medication for depression and symptoms are well controlled are eligible to participate
- Participant is at imminent risk of self-harm
- History of malignancy ≤ 5 years prior to study, except for adequately treated basal cell or squamous cell skin cancer, or in situ cervical cancer
- History of gastric or small intestinal surgery (including gastric bypass
surgery or banding), or presence of a disease that causes malabsorption
- Participant has recent history (within the last year) of drug or alcohol abuse or dependence or is a user of recreational or illicit drugs
- Participant is legally or mentally incapacitated
- Donation of blood products or phlebotomy of > 300 ml within 8
weeks of study, or intent to donate blood products or receive
blood products within 30 days of screening and throughout study
- Intent to donate eggs or sperm within the projected duration of the
study
- Current participation in or participation within 30 days of screening
in a study with an investigational compound or device
- Previous exposure to MK-0974 and/or MK-3207
- Use within the past 2 months of an opioid- or barbiturate-containing
analgesic for migraine relief
- Inpatient or emergency department treatment of an acute migraine
attack within the past 2 months