Antiplatelet Therapy Guided by Thrombelastography in Patients With Acute Coronary Syndromes (TEGCOR Study)

Antiplatelet Therapy Guided by Thrombelastography in Patients With Acute Coronary Syndromes (TEGCOR Study)

Personalized treatment approaches and antiplatelet drug choice have been proposed to optimize safety of coronary stenting by reducing heart attacks and repeat interventions while simultaneously minimizing adverse bleeding events. This study compares the efficacy of two laboratory guided treatment algorithms to personalize antiplatelet medication choice after coronary stenting

Inclusion Criteria:

• Patients admitted with acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction) and referred for coronary angiography.
• Current therapy with clopidogrel (at least 300mg loading dose, or 75mg po daily for >5 days)
• Age range 21-75 years.

Exclusion Criteria:

• Unable to give consent
• Age younger than 21 years, greater than 75 years
• History of stroke
• Body weight <60 kg
• Acute STEMI,
• Thrombocytopenia<100'000,
• requirement for chronic warfarin therapy