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The purpose of this study is to assess eyelid margin staining, termed "lid wiper epitheliopathy" (LWE), in three populations. The hypothesis is LWE will be more prevalent in symptomatic contact lens wearers than non-symptomatic contact lens wearers and least prevalent in asymptomatic non-contact lens wearers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Symptomatic Lens Wearers | Contact lens wearers reporting a habitual wear time of less than eight hours and a noticeable reduction in comfort over a wearing day |
| |
| Non-Symptomatic Contact Lens Wearers | Contact lens wearers reporting a comfortable wear time of more than 10 hours and minimal reduction in comfort over a wearing day |
| |
| Asymptomatic Non-Contact Lens Wearers | Non-contact lens wearers reporting a minimal reduction in ocular comfort over the course of a day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ophthalmic dye | Other | Topically instilled for the purpose of assessing lid margin staining |
|
| Measure | Description | Time Frame |
|---|---|---|
| LWE-associated staining score | Lens wearers must wear lenses for a minimum of 8 hours on the day of assessment, after which lenses will be removed and dye will be instilled. LWE-associated staining will be assessed by the investigator and reported as a composite score based on Korb's method. | 3 minutes after dye instillation |
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Inclusion Criteria:
Exclusion Criteria:
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Participants will be identified and screened by the University of Waterloo in Ontario, Canada.
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| Name | Affiliation | Role |
|---|---|---|
| Lyndon Jones, FCOptom, PhD | Centre for Contact Lens Research, School of Optometry, University of Waterloo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre for Contact Lens Research, University of Waterloo | Waterloo | N2L 3G1 | Canada |
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D019793 | Fluorescein |
| D003261 | Contact Lenses |
| ID | Term |
|---|---|
| D005452 | Fluoresceins |
| D013141 | Spiro Compounds |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
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|
| Contact lenses | Device | Silicone hydrogel contact lenses per subject's habitual brand and power, worn for a minimum of 8 hours on the day of assessment, after which lenses will be removed and dye will be instilled. |
|
| D009930 |
| Organic Chemicals |
| D014966 | Xanthenes |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D011083 | Polycyclic Compounds |
| D007909 | Lenses |
| D055096 | Optical Devices |
| D004864 | Equipment and Supplies |