PI left institution

The purpose of this trial is to measure ALA-induced fluorescence in both normal and malignant tissue.

Inclusion Criteria:

• Inclusion Criteria Patients (12 total patients with lung cancer) meeting eligibility criteria will be enrolled.
• Preoperative diagnosis of either presumed or documented non-small cell lung cancer.
• Tumor judged to be suitable for surgical resection based on preoperative evaluation of radiographic studies, pulmonary function tests, performance status and clinical judgment of surgeons at DHMC (Erkmen, Nugent)
• Age ≥ 18 years old.
• Population representative of our usual referral pattern including minority populations, women and those who are financially disadvantaged.
• Subjects capable of giving informed consent

Exclusion Criteria:

• Pregnant Women
• Women who are breast feeding
• History of cutaneous photosensitivity
• Porphyria, hypersensitivity to porphyrins, photodermatosis
• Exfoliative dermatitis
• History of liver disease within the last 12 months
• Inability to comply with photosensitivity precautions associated with the study
• Inability to give informed consent
• AST, ALT, ALP or bilirubin levels greater than 2.5 times the normal limit at any time during the past 2 months
• Plasma creatinine in excess of 180 umol/L
• Women who are breast feeding
• History of cutaneous photosensitivity
• Porphyria, hypersensitivity to porphyrins, photodermatosis
• Exfoliative dermatitis
• History of liver disease within the last 12 months
• Inability to comply with photosensitivity precautions associated with the study