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Gingival inflammation has been associated with cardiovascular diseases, including heart attack and stroke, because of elevation of blood risk markers such as cholesterol, glucose and C reactive protein. The treatment of gingival diseases decreases the concentration of these risk factors in the blood of cardiovascular patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Comprehensive treatment | Experimental | Test treatment group |
|
| Community treatment | Other | Control treatment group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Subgingival scaling and root planing | Device | Oral hygiene instruction and motivation will be provided altogether with scaling and root planing of all teeth affected by periodontitis under local anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in C reactive protein | Baseline, 3, 6 and 12 months | |
| Changes in flow-mediated dilation | Baseline, 1, 3 and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Interleukin 1B concentrations | Baseline, 3, 6, 12 months | |
| Changes in TNF alpha | Baseline, 3, 6, 12 months | |
| Changes in Interleukin 8 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alex N Haas, PhD | Federal University of Rio Grande do Sul, Periodontology | Study Chair |
| Cassiano K Rosing, PhD | Federal University of Rio Grande do Sul, Periodontology | Study Chair |
| Carisi Polanczyk, PhD | Federal University of Rio Grande do Sul, Cardiology | Study Chair |
| Eneida RR Rabelo da Silva, PhD | Federal University of Rio Grande do Sul | Study Chair |
| Marco A Saffi, MS | Federal University of Rio Grande do Sul, Cardiology | Principal Investigator |
| Cassio Kampits, MS | Federal University of Rio Grande do Sul, Periodontology | Principal Investigator |
| Ingrid Sanada, MS | Federal University of Rio Grande do Sul, Periodontology | Principal Investigator |
| Marlon Montenegro, MS | Federal University of Rio Grande do Sul, Periodontology | Principal Investigator |
| Mariana V Furtado, MS | Federal University of Rio Grande do Sul, Cardiology |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal University of Rio Grande do Sul, School of Dentistry and University Hospital | Porto Alegre | Rio Grande do Sul | 90035003 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21324167 | Background | Ramirez JH, Arce RM, Contreras A. Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial. Trials. 2011 Feb 16;12:46. doi: 10.1186/1745-6215-12-46. | |
| 18294231 | Background | Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 2008 Apr;35(4):277-90. doi: 10.1111/j.1600-051X.2007.01173.x. Epub 2008 Feb 20. |
| Label | URL |
|---|---|
| School of Dentistry homepage | View source |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D058226 | Plaque, Atherosclerotic |
| D003324 | Coronary Artery Disease |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
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| ID | Term |
|---|---|
| D012534 | Dental Scaling |
| D016745 | Root Planing |
| ID | Term |
|---|---|
| D003777 | Dental Prophylaxis |
| D010517 | Periodontics |
| D003813 | Dentistry |
| D011313 | Preventive Dentistry |
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| Oral prophylaxis | Device | One session of supraginigval calculus removal |
|
| Baseline, 3, 6, 12 months |
| Changes in Interleukin 6 | Baseline, 3, 6, 12 months |
| Changes in Cholesterol | Baseline, 3, 6, 12 months |
| Changes in Glycated hemoglobin | Baseline, 3, 6, 12 months |
| Changes in LDL/HDL | Baseline, 3, 6, 12 months |
| Changes in Fibrinogen | Baseline, 3, 6, 12 months |
| Study Director |
| 19774803 | Background | Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J. 2009 Aug;59(4):197-209. |
| 22514251 | Background | Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Taubert KA, Newburger JW, Gornik HL, Gewitz MH, Wilson WR, Smith SC Jr, Baddour LM; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Council on Clinical Cardiology. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association. Circulation. 2012 May 22;125(20):2520-44. doi: 10.1161/CIR.0b013e31825719f3. Epub 2012 Apr 18. |
| 30761568 | Derived | Montenegro MM, Ribeiro IWJ, Kampits C, Saffi MAL, Furtado MV, Polanczyk CA, Haas AN, Rosing CK. Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months. J Clin Periodontol. 2019 Mar;46(3):321-331. doi: 10.1111/jcpe.13085. Epub 2019 Mar 6. |
| 24010954 | Derived | Saffi MA, Furtado MV, Montenegro MM, Ribeiro IW, Kampits C, Rabelo-Silva ER, Polanczyk CA, Rosing CK, Haas AN. The effect of periodontal therapy on C-reactive protein, endothelial function, lipids and proinflammatory biomarkers in patients with stable coronary artery disease: study protocol for a randomized controlled trial. Trials. 2013 Sep 6;14:283. doi: 10.1186/1745-6215-14-283. |
| University Hospital homepage | View source |
| D006331 | Heart Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D013357 |
| Subgingival Curettage |