The purpose is to study the relationship between RA disease activity based on Doppler quantification and the subsequent clinical response (EULAR response) to treatment with Adalimumab during 12 months. The purpose is also to compare the Doppler quantification with conventional clinical methods and semiquantitative Doppler assessment.

Inclusion Criteria:

• Adult patient (> 18 years of age), male or female
• Rheumatoid arthritis according to the 1987 ACR or 2010 EULAR/ACR classification criteria
• Moderate to high disease activity
• Ongoing anti-rheumatic treatment with DMARD, with stable dosage during the last 3 months, and being a candidate for anti-TNF add-on therapy OR ongoing treatment with first anti-TNF therapy and being a candidate for switch to another anti-TNF therapy
• Women with child-bearing potential: use of an adequate method of contraception to avoid pregnancy throughout the study
• Signed Informed Consent *Signed Informed Consent must be obtained before any study specific procedures take place.

Exclusion Criteria:

• Biologic treatment with Adalimumab before inclusion
• Two or more ongoing biologic treatments before inclusion
• Treatment with other biologic treatment than anti-TNF therapy before inclusion
• Any contraindication for treatment with Adalimumab
• Intraarticular corticosteroid injection during the last 4 weeks before each follow-up visit
• Positive for tuberculosis or hepatitis B.
• Ongoing pregnancy or lactation