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This observational, multicenter, retrospective/prospective study will evaluate the use of Avastin (bevacizumab) in clinical practice in patients with metastatic colorectal cancer. Patients having initiated first-line treatment with a fluoropyrimidine-based chemotherapy and Avastin will be followed for up to 15 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort |
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with Avastin treatment discontinuation due to either disease progression or Avastin-related adverse events | approximately 15 months |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with treatment discontinuation due to other causes | approximately 15 months | |
| Incidence of other causes for treatment discontinuation | approximately 15 months | |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with metastatic colorectal cancer having initiated first-line treatment with fluoropyrimidine-based chemotherapy and Avastin
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| L’Aquila | Abruzzo | 67010 | Italy | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30857495 | Derived | Lonardi S, Nasti G, Fagnani D, Gemma D, Ciuffreda L, Granetto C, Lucchesi S, Ballestrero A, Biglietto M, Proserpio I, Bergamo F, Proietti E, Tonini G. Discontinuation of first-line bevacizumab in metastatic colorectal cancer: the BEAWARE Italian Observational Study. Tumori. 2019 Jun;105(3):243-252. doi: 10.1177/0300891619834126. Epub 2019 Mar 11. |
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| Second-line treatments initiated |
| approximately 15 months |
| Progression-free survival (patients with treatment discontinuation due to disease progression or Avastin-related toxicity as compared to patients with treatment discontinuation due to other causes) | approximately 15 months |
| Teramo |
| Abruzzo |
| 64100 |
| Italy |
| Brindisi | Apulia | 72100 | Italy |
| Castellana Grotte (BA) | Apulia | 70013 | Italy |
| Foggia | Apulia | 71100 | Italy |
| Lecce | Apulia | 73100 | Italy |
| San Giovanni Rotondo | Apulia | 71013 | Italy |
| Rionero in Vulture | Basilicate | 85028 | Italy |
| Cosenza | Calabria | 87100 | Italy |
| Lamezia Terme (CZ) | Calabria | 88046 | Italy |
| Reggio Calabria | Calabria | 89100 | Italy |
| Benevento | Campania | 82100 | Italy |
| Naples | Campania | 80100 | Italy |
| Naples | Campania | 80131 | Italy |
| Pagani ( Sa) | Campania | 84016 | Italy |
| Imola (BO) | Emilia-Romagna | 40026 | Italy |
| Modena | Emilia-Romagna | 41100 | Italy |
| Parma | Emilia-Romagna | 43100 | Italy |
| Pordenone | Friuli Venezia Giulia | 33170 | Italy |
| Albano Laziale | Lazio | 00041 | Italy |
| Rome | Lazio | 00128 | Italy |
| Rome | Lazio | 00157 | Italy |
| Rome | Lazio | 00185 | Italy |
| Rome | Lazio | 00189 | Italy |
| Sora | Lazio | 03039 | Italy |
| Viterbo | Lazio | 01100 | Italy |
| Genoa | Liguria | 16132 | Italy |
| La Spezia | Liguria | 19100 | Italy |
| Savona | Liguria | Italy |
| Bergamo | Lombardy | 24121 | Italy |
| Brescia | Lombardy | 25124 | Italy |
| Cremona | Lombardy | 26100 | Italy |
| Lecco | Lombardy | 23900 | Italy |
| Milan | Lombardy | 20099 | Italy |
| Milan | Lombardy | 20142 | Italy |
| Monza | Lombardy | 20900 | Italy |
| Pavia | Lombardy | 27100 | Italy |
| S. Fermo Della Battaglia (CO) | Lombardy | 22020 | Italy |
| Saronno | Lombardy | 21047 | Italy |
| Varese | Lombardy | 21100 | Italy |
| Cuneo | Piedmont | 12100 | Italy |
| Novara | Piedmont | 28100 | Italy |
| Orbassano | Piedmont | 10043 | Italy |
| Ponderano (BI) | Piedmont | 13875 | Italy |
| Turin | Piedmont | 10126 | Italy |
| Turin | Piedmont | 10153 | Italy |
| Cagliari | Sardinia | 09121 | Italy |
| Sassari | Sardinia | 07100 | Italy |
| Catania | Sicily | 95123 | Italy |
| Cefalù | Sicily | 90015 | Italy |
| Messina | Sicily | 98125 | Italy |
| Messina | Sicily | 98158 | Italy |
| Palermo | Sicily | 90100 | Italy |
| Taormina | Sicily | 98030 | Italy |
| Vimercate | Sicily | 20059 | Italy |
| Fano | The Marches | 61032 | Italy |
| Fermo | The Marches | 63023 | Italy |
| Province of Macerata | The Marches | 62100 | Italy |
| Grosseto | Tuscany | 58100 | Italy |
| Lido di Camaiore | Tuscany | 55043 | Italy |
| Livorno | Tuscany | 57100 | Italy |
| Pontedera | Tuscany | 56025 | Italy |
| Siena | Tuscany | 53100 | Italy |
| Perugia | Umbria | 06156 | Italy |
| Cona (Ferrara) | Veneto | 44124 | Italy |
| Este | Veneto | 35042 | Italy |
| Este (PD) | Veneto | 35042 | Italy |
| Mirano | Veneto | 30035 | Italy |
| Montecchio Maggiore | Veneto | 36075 | Italy |
| Padova | Veneto | 35128 | Italy |
| Rovigo | Veneto | 45100 | Italy |
| Treviso | Veneto | 31100 | Italy |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
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