Platelet Inhibition and Bleeding in Patients Undergoing Non-Cardiac Surgery

Does Platelet Inhibition Predict Surgery Related Bleeding in Patients Undergoing Non-Cardiac Surgery During Dual Antiplatelet Therapy

The aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing non-cardiac surgery during dual antiplatelet therapy.

Inclusion Criteria:

• intake of Clopidogrel, Prasugrel, or Ticagrelor within the last 7 days
• spontaneous bleeding or impeding surgery (major vascular surgery, intraperitoneal or intrathoracic surgery, ENT-surgery, orthopedic or trauma surgery, prostatic surgery)

Exclusion Criteria:

• concomitant medication with warfarin
• renal insufficiency needing dialysis
• concomitant therapy with GPIIB/IIIA Antagonists
• expected duration of operation >30min