The HIV-2 is less common ie 1-2 million people in West Africa. HIV-2 does have the same sensitivity to antiretroviral treatment (ART) compared to HIV-1. The ART strategies that are appropriate for the HIV-1 infection are not as effective for HIV-2. Classical triple therapy including PI is less effective for HIV-2. Also, the choice of ARTs in a second line treatment is limited. The first line optimal treatment has to be defined by a prospective and randomized evaluation of other strategies. The primary endpoint will be adapted to the specificity of the HIV-2 infection. The 1st step is to define, with a phase II clinical trial, whether a strategy including 2 NRTIs and raltegravir, as an alternative strategy to the classical triple therapy, shows an immunovirological response, at least, as good as the one obtained with the triple therapy. The hypothesis is that the low ART response observed in HIV-2 infection is due to a low virological strength of the ARTs used and that the combination of 2 NRTIs and raltegravir should show a therapeutic success of at least 50% at week 48.

Inclusion Criteria:

• age ≥18 years
• HIV-2 mono infection, confirmed by ELISA and Western Blot test or Immunoblot,
• antiretroviral treatment-naive, whatever the duration and indication of prior treatments,
• indication to treatment, with at least one of the following criteria : type B or C events, CD4 lymphocytes count below 500/mm3 at screening-visit or CD4 lymphocytes count decrease of at least 50 cell/µL/year over the last 3 years with the last CD4 lymphocytes count within -/+ 10 % of the nadir, plasma HIV-2 RNA load over or equal to 100 copies/mL at screening-visit,
• Pneumocystis prophylaxis if CD4 lymphocytes count below 200/mm3, combined to a toxoplasmosis prophylaxis in case of a positive toxoplasmosis serology,
• French residency for at least one year,
• Written informed consent, signed by the participant and the investigator (at the latest on the screening-visit and prior any study related intervention)
• Affiliate or beneficiary of a social security system (State Medical Assistance is not a social security scheme).

Exclusion Criteria:

• Absence of effective contraception method(women),
• Pregnancy, breastfeeding or wish for pregnancy during the trial,
• Curative treatment of a progressive opportunistic infection not compatible with those evaluated in the present study,
• Malignant or tumorous affection requiring chemotherapy or radiotherapy,
• Decompensated cirrhosis,
• Viral hepatitis C with a Metavir score over F2,
• Hemoglobinemia below 7g/dL, polynuclear neutrophils below 500/mm3, platelets below 50 000/mm3, creatinine clearance below 50 mL/mn, transaminase, alkaline phosphatase or bilirubin over 2.5N,
• Contraindication to one of the excipients of study treatments,
• Insuline-dependent diabetes mellitus not well controlled (with glycated haemoglobin (HbA1C) over 7%),
• Long-term corticosteroid treatment (more than 3 weeks of treatment),
• Judicial protection, legal guardianship,
• Participation in other therapeutic trial or comprising an exclusion period ongoing at the time of the screening-visit.