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The purpose of this study is to evaluate the long-term safety and effectiveness of growth hormone (Eutropin Inj./Eutropin plus Inj.) treatment with GHD (Growth Hormone Deficiency), TS (Turner Syndrome),CRF (Chronic Renal Failure), SGA (Small for Gestational Age), and ISS (Idiopathic Short Stature).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| growth hormone |
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| Measure | Description | Time Frame |
|---|---|---|
| Safety measure : adverse event | up to 2 years after epiphyseal closure |
| Measure | Description | Time Frame |
|---|---|---|
| effectiveness measure : difference in target height and final height | up to 2 years after epiphyseal closure | |
| effectiveness : difference in height velocity between Baseline and every year | up to 2 years after epiphyseal closure |
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Inclusion Criteria:
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children with GHD, TS, CRF, SGA and ISS
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| YoungHwan Jang | Contact | 82-2-6924-3158 | younghj@lgls.com |
| Name | Affiliation | Role |
|---|---|---|
| HW Chae, M.D. | Kangnam severance hospital | Principal Investigator |
| KS Sim, M.D. | Kangdong KyungHee University hospital | Principal Investigator |
| IT Hwang, M.D. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41493505 | Derived | Lee HS, Rhie YJ, Kim J, Chae HW, Lee YA, Kim YM, Kim JH, Hong YH, Ahn MB, Hwang JS. Long-Term experience with growth hormone therapy in pediatric growth disorders: an analysis of the LG growth study data. Endocrine. 2026 Jan 6;91(1):31. doi: 10.1007/s12020-025-04535-x. | |
| 39901524 | Derived | Kim JH, Kim SJ, Chung IH, Lim JS. Adiposity Rebound Timing in Small for Gestational Age Children Treated With Growth Hormone: Results From LG Growth Study Data. J Korean Med Sci. 2025 Feb 3;40(4):e12. doi: 10.3346/jkms.2025.40.e12. |
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| ID | Term |
|---|---|
| D004393 | Dwarfism, Pituitary |
| D014424 | Turner Syndrome |
| D007676 | Kidney Failure, Chronic |
| ID | Term |
|---|---|
| D004392 | Dwarfism |
| D001848 | Bone Diseases, Developmental |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| effectiveness measure : difference in height SDS for CA between baseline and every 6 months | up to 2 years after epiphyseal closure |
| Kangdong Sacred Heart Hospital |
| Principal Investigator |
| SC Chung, M.D. | Konkook University hospital | Principal Investigator |
| CW Ko, M.D. | Kyungpook National University Hospital | Principal Investigator |
| HS Kim, M.D. | Keimyung University hospital | Principal Investigator |
| YJ Lee, M.D. | Korea University | Principal Investigator |
| KH Lee, M.D. | Korea University Anam Hospital | Principal Investigator |
| JH Lee, M.D. | Kosin university hospital | Principal Investigator |
| JS Yu, M.D. | Dankook University | Principal Investigator |
| JH Yu, M.D. | Dong-A University Hospital | Principal Investigator |
| SY Lee, M.D. | SMG-SNU Boramae Medical Center | Principal Investigator |
| WY Chung, M.D. | Inje University | Principal Investigator |
| Yl Shin, M.D. | Buchun Soonchunhyang university hospital | Principal Investigator |
| CY Kim, M.D. | daejin medical center | Principal Investigator |
| DK Jin, M.D. | Samsung Medical Center | Principal Investigator |
| MJ Park, M.D. | Inje University | Principal Investigator |
| CH Shin, M.D. | Seoul National University Hospital | Study Chair |
| BK Suh, M.D. | Seoul St. Mary's Hospital | Principal Investigator |
| HW Yoo, M.D. | Asan Medical Center | Principal Investigator |
| MH Jung, M.D. | Yeouide St. Mary's hospital | Principal Investigator |
| SH Park, M.D. | St Vincent's Hospital | Principal Investigator |
| DH Kim, M.D. | Sowha children's hospital | Principal Investigator |
| DH Lee, M.D. | Seoul Soonchunhyang university hospital | Principal Investigator |
| HS Kim, M.D. | Sinchon severance hospital | Principal Investigator |
| JS Hwang, M.D. | Ajou University School of Medicine | Principal Investigator |
| SY Kim, M.D. | Pusan National University Yangsan Hospital | Principal Investigator |
| JD Kim, M.D. | Wonkwang university school of medicine & hospital | Principal Investigator |
| HS Han, M.D. | Chungbuk National University Hospital | Principal Investigator |
| KH Lee, M.D. | Wonkwang University | Principal Investigator |
| EK Yoo, M.D. | Bunsangcha hospital | Principal Investigator |
| BK Lim, M.D. | Wonju Christian Hospital | Principal Investigator |
| JH Kang, M.D. | Eulji University Hospital | Principal Investigator |
| JY Seo, M.D. | Eulji General Hospital | Principal Investigator |
| HS Kim, M.D. | ehwa university medical center | Principal Investigator |
| JE Lee, M.D. | Inha University Hospital | Principal Investigator |
| JH Kim, M.D. | Inje University | Principal Investigator |
| CJ Kim, M.D. | Chonnam National University Hospital | Principal Investigator |
| DY Lee, M.D. | Chonbuk National University Hospital | Principal Investigator |
| KS Shin, M.D. | Jeju National University Hospital | Principal Investigator |
| IT Hwang, M.D. | Hallym University Medical Center | Principal Investigator |
| SM Lee, M.D. | Hanyang University | Principal Investigator |
| KH Lee, M.D. | Korea University Guro Hospital | Principal Investigator |
| KS Jo, M.D. | Bucheon St. Mary's Hospital | Principal Investigator |
| SY Ahn, M.D. | KangWon National University Hospital | Principal Investigator |
| PS Oh, M.D. | Chuncheon Sacred Heart Hospital | Principal Investigator |
| S Yang, M.D. | Hallym University Kangnam Sacred Heart Hospital | Principal Investigator |
| EY Kim, M.D. | Chosun University Hospital | Principal Investigator |
| 39676465 | Derived | Jeong HR, Lee HS, Hwang JS. Growth Prediction Model for Prepubertal Children With Idiopathic Growth Hormone Deficiency: An Analysis of LG Growth Study Data. Clin Endocrinol (Oxf). 2025 Mar;102(3):281-287. doi: 10.1111/cen.15178. Epub 2024 Dec 15. |
| 35472208 | Derived | Lee HS, Kum CD, Rho JG, Hwang JS. Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data. PLoS One. 2022 Apr 26;17(4):e0266329. doi: 10.1371/journal.pone.0266329. eCollection 2022. |
| 35315601 | Derived | Lim HH, Kim YM, Lee GM, Yu J, Han HS, Yu J. Growth Responses During 3 Years of Growth Hormone Treatment in Children and Adolescents With Growth Hormone Deficiency: Comparison Between Idiopathic, Organic and Isolated Growth Hormone Deficiency, and Multiple Pituitary Hormone Deficiency. J Korean Med Sci. 2022 Mar 21;37(11):e90. doi: 10.3346/jkms.2022.37.e90. |
| 32419399 | Derived | Cho WK, Ahn MB, Kim EY, Cho KS, Jung MH, Suh BK. Predicting First-Year Growth in Response to Growth Hormone Treatment in Prepubertal Korean Children with Idiopathic Growth Hormone Deficiency: Analysis of Data from the LG Growth Study Database. J Korean Med Sci. 2020 May 18;35(19):e151. doi: 10.3346/jkms.2020.35.e151. |
| D001849 |
| Bone Diseases, Endocrine |
| D007018 | Hypopituitarism |
| D010900 | Pituitary Diseases |
| D007027 | Hypothalamic Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D004700 | Endocrine System Diseases |
| D006059 | Gonadal Dysgenesis |
| D012734 | Disorders of Sex Development |
| D014564 | Urogenital Abnormalities |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D058533 | Sex Chromosome Disorders of Sex Development |
| D052801 | Male Urogenital Diseases |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D025064 | Sex Chromosome Disorders |
| D025063 | Chromosome Disorders |
| D030342 | Genetic Diseases, Inborn |
| D006058 | Gonadal Disorders |
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |