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Hypothesis: Morphine infusion decreases time to mechanical ventilation weaning and extubation, as compared to the combination of fentanyl and midazolam in critically-ill patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morphine | Experimental |
| |
| Fentanyl and Midazolam | Active Comparator | Control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Morphine infusion | Drug | Conventional dose |
| |
| Fentanyl and Midazolam infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Time from sedation discontinuation to first T-Tube time from sedation | 12-120 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Time from sedation discontinuation to extubation time from sedation | 12-180 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Efrain Riveros, Principal investigator | Clinica de los Andes IPS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinica de los Andes IPS | Tunja | Departamento de Boyacá | 8 | Colombia |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D005283 | Fentanyl |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Drug |
Conventional dose |
|