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The purpose of this study is to evaluate the PK/PD parameters, safety and efficacy of extended infusion of beta-lactams in intensive care patients who are infected with Gram-negative bacteremia or pneumonia at National Taiwan University Hospital (NTUH).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intermittent infusion | Active Comparator |
| |
| extended infusion | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beta-Lactams | Drug | infusion time: 30 mins or 1 hr |
| |
| Measure | Description | Time Frame |
|---|---|---|
| serum concentrations of beta-lactams | Determination of serum concentrations of beta-lactams | 6 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shu-Wen Lin, Pharm D. | Contact | (02)2312-3456 | 88372 | shuwenlin@ntu.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Shu-Wen Lin, Pharm D. | National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NTUH | Recruiting | Taipei | 100 | Taiwan |
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| Beta-Lactams |
| Drug |
infusion time 4 hrs |
|
| ID | Term |
|---|---|
| D016905 | Gram-Negative Bacterial Infections |
| ID | Term |
|---|---|
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D047090 | beta-Lactams |
| ID | Term |
|---|---|
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013457 | Sulfur Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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