Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

The specific aims of this investigation in children during burn rehabilitation include 1.) to determine the efficacy of melatonin intervention on improving sleep-related outcomes 2.) investigate the hypothesis that sleep inadequacy is associated with cognitive deficits and 3.) develop a new methodology specific for burn patients that accurately screens for the presence of intrinsic dyssomnia.

Inclusion Criteria:

• History of burn injury
• Scheduled for an elective surgical procedure
• 5 - 22 years of age, inclusive

Exclusion Criteria:

• History of anoxic brain injury
• History of head injury within the last year
• Pre-existing seizure disorder
• Pre-existing neurological disorder
• Pre-existing blindness
• Known hypersensitivity to melatonin
• Anticoagulant use or aspirin therapy
• Antihypertensive medication use
• Diabetes mellitus or other endocrine disorders
• Autoimmune disorders
• Schizophrenia
• Inability to access internet
• Intellectual disability or inability to follow directions