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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-015725-37 | EudraCT Number |
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The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cyclosporine A | Experimental | Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation |
|
| Control | Active Comparator | usual care of cardiac arrest |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cyclosporine A | Drug | Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sequential Organ Failure Assessment score (SOFA) | At 24 hours after hospital admission |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital admission with return of spontaneous circulation | At 24 hours following admission, at day 28, at hospital discharge (an average time frame of 7 days) | |
| Survival | At 24 hours following admission, at day 28, and at hospital discharge (an average time frame of 7 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laurent ARGAUD, MD, PhD | Groupement Hospitalier Edouard Herriot,69437 Lyon Cedex 03 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical intensive care unit, Edouard Herriot Hospital | Lyon | 69003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27433815 | Result | Argaud L, Cour M, Dubien PY, Giraud F, Jossan C, Riche B, Hernu R, Darmon M, Poncelin Y, Tchenio X, Quenot JP, Freysz M, Kamga C, Beuret P, Usseglio P, Badet M, Anette B, Chaulier K, Alasan E, Sadoune S, Bobbia X, Zeni F, Gueugniaud PY, Robert D, Roy P, Ovize M; CYRUS Study Group. Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial. JAMA Cardiol. 2016 Aug 1;1(5):557-65. doi: 10.1001/jamacardio.2016.1701. | |
| 34116828 |
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D000080942 | Post-Cardiac Arrest Syndrome |
| D009102 | Multiple Organ Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
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| ID | Term |
|---|---|
| D016572 | Cyclosporine |
| D016887 | Cardiopulmonary Resuscitation |
| ID | Term |
|---|---|
| D003524 | Cyclosporins |
| D010456 | Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
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| cardio-pulmonary resuscitation | Procedure | usual care of cardiac arrest |
|
| Good cerebral outcome | Glasgow Coma Scale and Cerebral Performance Categories | At 24 hours following admission, at day 28, and at hospital discharge (an average time frame of 7 days) |
| All adverse events | until hospital discharge (an average time frame of 7 days) |
| Derived |
| Madelaine T, Cour M, Roy P, Vivien B, Charpentier J, Dumas F, Deye N, Bonnefoy E, Gueugniaud PY, Coste J, Cariou A, Argaud L. Prediction of Brain Death After Out-of-Hospital Cardiac Arrest: Development and Validation of the Brain Death After Cardiac Arrest Score. Chest. 2021 Jul;160(1):139-147. doi: 10.1016/j.chest.2021.01.056. Epub 2021 Jun 8. |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D015427 | Reperfusion Injury |
| D014652 | Vascular Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
| D010455 |
| Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012151 | Resuscitation |
| D004638 | Emergency Treatment |
| D013812 | Therapeutics |