Cyclosporine A in Cardiac Arrest

CYclosporine A in Non-shockable Out-of-hospital Cardiac Arrest ResUScitation

The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.

Inclusion Criteria:

• Witnessed out-of-hospital cardiac arrest
• Non shockable cardiac rhythm

Exclusion Criteria:

• Evidence of trauma
• Evidence of pregnancy
• Duration of no flow more than 30 minutes
• Rapidly fatal underlying disease
• Allergy to cyclosporin A