Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis

Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis: Single-center, Randomized, Controlled Trial

The purpose of this study is to determine the effect and safety of early high-volume continuous veno-venous hemofiltration for patients with severe acute pancreatitis.

The investigators anticipated that early high-volume continuous veno-venous hemofiltration (EHVCVVH) would result in a decrease of the composite of persistent organ failure or death by eliminating inflammatory mediators in blood. This study is designed to evaluate the impact of EHVCVVH on patients with severe acute pancreatitis.

Inclusion Criteria:

• clinical diagnosis of severe acute pancreatitis
• written informed consent
• Time from onset of abdominal pain to admission ≤ 72 hours
• SIRS score ≥ 2

Exclusion Criteria:

• confirmed infection
• pregnancy
• patients needing emergency operation for abdominal compartment syndrome
• chronic renal diseases needing blood purification
• previous exploratory laparotomy for acute abdomen and diagnosis of pancreatitis during laparotomy
• acute flare-up of chronic pancreatitis
• malignancy