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The purpose of this study is to test the effects of cannabinoids on pain response using a variety of human experimental pain models.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| THC 0.01 mg/kg | Active Comparator |
| |
| Placebo | Placebo Comparator |
| |
| THC 0.03 mg/kg | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thermal | Other | Thermal sensation/pain testing |
|
| Measure | Description | Time Frame |
|---|---|---|
| Capsaicin-induced hyperalgesia | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Measures | On each test day at baseline (-30), peak (+20) and post (+120) drug administration | |
| Non-pain subjective responses | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Deepak C D'Souza, M.D. | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Connecticut Healthcare System | West Haven | Connecticut | 06516 | United States |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019966 | Substance-Related Disorders |
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| ID | Term |
|---|---|
| D004560 | Electricity |
| D002211 | Capsaicin |
| D013759 | Dronabinol |
| ID | Term |
|---|---|
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
| D055585 | Physical Phenomena |
| D053284 | Polyunsaturated Alkamides |
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| Electrical | Other | Electrical sensation/pain testing |
|
| Capsaicin | Other | Intradermal Capsaicin |
|
| THC | Drug | Active THC (0.01 mg/kg) administered over 10 minutes |
|
|
| THC | Drug | Active THC (0.03 mg/kg) administered over 10 minutes |
|
|
| Placebo | Drug | Control: small amount of alcohol with no THC, administered over 10 minutes |
|
| Cognitive subjective responses | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000475 | Alkenes |
| D006839 | Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D005229 | Fatty Acids, Monounsaturated |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D002186 | Cannabinoids |
| D013729 | Terpenes |