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| Name | Class |
|---|---|
| Sahlgrenska University Hospital | OTHER |
| The Swedish Research Council | OTHER_GOV |
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The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM.
Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fibromyalgia | Women with fibromyalgia, aged 20-50 years | ||
| Healthy controls | Women without severe disease, aged 20-50 years |
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| Measure | Description | Time Frame |
|---|---|---|
| IGF1 level | Ergometer cycle test of 15 minutes at low respective high intensity. Blood test is done before and after exercise. Change in quantity of IGF1 is measured. | 15 min |
| Measure | Description | Time Frame |
|---|---|---|
| Pain rating | Pain is rated by the test person before and after the ergometer cycle test. | 15 minutes |
| Pain threshold | Pain threshold is measured before and after the ergometer test. |
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Inclusion Criteria:
Exclusion Criteria:
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The participants are recruited from previous studies.
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| Name | Affiliation | Role |
|---|---|---|
| Kaisa Mannerkorpi, Assoc prof | Göteborg University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sahlgrenska University Hospital, Dept of Physical Therapy | Gothenburg | 41345 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28122522 | Result | Mannerkorpi K, Landin-Wilhelmsen K, Larsson A, Cider A, Arodell O, Bjersing JL. Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia. BMC Musculoskelet Disord. 2017 Jan 25;18(1):37. doi: 10.1186/s12891-017-1402-y. |
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| ID | Term |
|---|---|
| D005356 | Fibromyalgia |
| D010146 | Pain |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D009468 | Neuromuscular Diseases |
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Blood serum
| 15 minutes |
| Interleukin 6 and 8 | Blood test is done before and after the ergometer bicycle test. Quantity of interleukin 6 and 8 is measured. | 15 minutes |
| D009422 |
| Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |