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A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects.
The aim of the study is to investigate whether caffeine or sodium citrate ingestion could enhance performance in spinal cord injured wheelchair athletes. It is a double blind, placebo controlled and randomized study.
The athletes have to complete four 1500m tests on a training roller. Before each treatment they get different supplementations. Once they get sodium citrate and a placebo, once caffeine and a placebo, once sodium citrate and caffeine and for the fourth treatment they get twice a placebo. Two hours after starting with the supplementation they have to complete the 1500m as fast as possible. Time to complete 1500m, blood pH, plasma bicarbonate, sodium concentration, heart rate, oxygen consumption, blood lactate concentration and rate of perceived exertion (RPE) were measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Caffeine | Active Comparator | 6mg per kg bodyweight ingested 60min before test |
|
| Placebo | Placebo Comparator | Sodium chloride and mannitol as placebo are ingested by the athlete |
|
| Sodium Citrate | Active Comparator | sodium citrate diluted in 7dl water, ingestion 120 to 90min prior test |
|
| Caffeine and Sodium Citrate | Active Comparator | sodium citrate 120-90min prior test capsules:60min prior test |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Caffeine | Dietary Supplement | gelatine capsule 6mg/kg bodyweight 60min prior test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time | Time to complete 1500m | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate | Heart Rate measured from 2min before the test until 5min after the 1500m-test. | during study phase of 3 week (4 tests) |
| Lactate Concentration | 1min before starting the warm up, 15s after the end of the warm up, 15s after completing the test, 2min/4min/6min/8min/10min after the test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Claudio Perret, Dr. sc. nat. | Swiss Paraplegic Research, Nottwil | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Swiss Paraplegic Centre | Nottwil | Canton of Lucerne | 6207 | Switzerland |
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| ID | Term |
|---|---|
| D002110 | Caffeine |
| D000077559 | Sodium Citrate |
| D008353 | Mannitol |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
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| Sodium Citrate | Dietary Supplement | 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test |
|
| Mannitol | Dietary Supplement | gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test |
|
| Sodium Chloride | Dietary Supplement | sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test |
|
| during the 3 weeks study phase |
| blood pH, sodium concentration and plasma bicarbonate | 1min before starting with the ingestion of the fluid, immediately before starting the warm up, just immediately before starting the 1500m test. | during the 3 weeks of study phase |
| Oxygen Consumption | oxygen consumption (VO2(ml/min/kg), VCO2(ml/min), RER (VCO2/VO2)) starting of the measurement is 2min before the start of the 1500m and ends 2min after having completed the 1500m | during 3 weeks of study phase |
| rating of gastrointestinal stress | 1min before starting to drink the fluid, 2min before starting with the warm up, 2min before the test and 2min after having completed the 1500m | during the 3 weeks of study phase |
| Rating of Perceived Exertion (RPE) | 15s after the end of the warm up, 15s after having completed the 1500m | during the 3 weeks of study phase |
| D011687 |
| Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D019343 | Citric Acid |
| D002951 | Citrates |
| D014233 | Tricarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D002241 | Carbohydrates |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |