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| Name | Class |
|---|---|
| University of Pennsylvania | OTHER |
| Mayo Clinic | OTHER |
| NYU Langone Health | OTHER |
| Johns Hopkins University |
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The purpose of this research study is to investigate the possibility that a person's genes put a person at a higher risk of developing mesothelioma. The investigators will examine genes from DNA (genetic material) isolated from blood. This study will also examine the impact of environmental and work exposures and family history of common cancers on the development of mesothelioma. The genetic markers in this study will basically identify how a person's body processes frequently encountered environmental pollutants and will not tell about chromosomes, specific diseases, or other potential health problems.
Mesothelioma is a cancer that develops from serosal surfaces usually in response to prior asbestos exposure. A history of asbestos exposure can be elicited in more than 80% of mesothelioma victims. However, asbestos exposure alone is not sufficient to cause the development of mesothelioma. Nearly 27 million individuals in the US, were exposed to asbestos in the work place between 1940 and 1979 but just 3,000 new cases of mesothelioma are diagnosed each year. Therefore, the investigators hypothesis is that genetic variation in addition to asbestos exposure, and host factors contribute to the development of mesothelioma. It is estimated, based on the investigators preliminary studies, that a population in excess of 1,000 subjects with mesothelioma is required to perform a valid GWAS.
Therefore a multicenter approach is necessary to collect data and DNA on sufficient numbers with mesothelioma to adequately evaluate genetic risk. It is the aim of this proposal to develop a consortium of mesothelioma investigators to share phenotypic data and DNA samples and to perform genome wide association scanning (GWAS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mesothelioma | Individuals who have been diagnosed with mesothelioma |
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| Measure | Description | Time Frame |
|---|---|---|
| Creation of a consortium of investigators (6 sites) for collection of blood for germline DNA and demographic information from 1000 mesothelioma subjects. | Demographic variables that will be collected include; date of birth, gender, age at first exposure to asbestos, type of exposure (occupational or bystander), family health history, personal past medical history, smoking history, age at diagnosis, latency, tumor location and cell type. | Participants will be seen on one occasion lasting 30-60 min to draw blood and elicit demographic information. It will require up to 2 years to enroll 1000 subjects with mesothelioma from the various sites. |
| Measure | Description | Time Frame |
|---|---|---|
| GWAS will be performed on the DNA from the 1000 subjects with mesothelioma and compared with 1000 age and asbestos exposure matched controls free of past personal history and family history of cancer. | Given the significant risk for cancers other than the index mesothelioma in both subjects and their 1st degree relative (nearly 3 fold for sibs, parents and the mesothelioma subjects themselves and 7 fold for their children), the goal is to identify SNPs involved with mesothelioma and other common cancer susceptibility. |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects will be recruited from the clinics and in patient wards of the academic medical centers noted as collaborators.
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| Name | Affiliation | Role |
|---|---|---|
| Jill Ohar, MD | Wake Forest University | Study Director |
| Lee Krug, MD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Julie Brahmer, MD | Johns Hopkins University | Principal Investigator |
| Harvey I Pass, MD | NYU Langone Health | Principal Investigator |
| Tobias Peikert, MD | Mayo Clinic | Principal Investigator |
| Daniel H Sterman, MD | University of Pennsylvania | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Baltimore | Maryland | 21287 | United States | ||
| Mayo Clinic |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16457426 | Background | Bertazzi PA. Descriptive epidemiology of malignant mesothelioma. Med Lav. 2005 Jul-Aug;96(4):287-303. | |
| 15559057 | Background | Paul S, Neragi-Miandoab S, Jaklitsch MT. Preoperative assessment and therapeutic options for patients with malignant pleural mesothelioma. Thorac Surg Clin. 2004 Nov;14(4):505-16, ix. doi: 10.1016/j.thorsurg.2004.06.008. |
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| ID | Term |
|---|---|
| D008654 | Mesothelioma |
| ID | Term |
|---|---|
| D000236 | Adenoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| OTHER |
| Memorial Sloan Kettering Cancer Center | OTHER |
| Mesothelioma Applied Research Foundation, Inc. | OTHER |
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whole blood
| It will take up to 1 year, after the collection of the 1000 mesothelioma samples, to perform and analyze the GWAS. |
| Rochester |
| Minnesota |
| 55905 |
| United States |
| New York University School of Medicine | New York | New York | 10016 | United States |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | United States |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States |
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| D018301 |
| Neoplasms, Mesothelial |