Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. So the investigators assumed that whether Sox2 plays an important role in the progression and migration of colon cancer.

In our study, we examined Sox2 expression in archived human colon cancer tissues and found that its Sox2 expression correlates with reduced patient survival, increased tumor grade and metastasis probability.

Inclusion Criteria:

• Clinical diagnosis of colorectal cancer

Exclusion Criteria:

• Clinical diagnosis characteristics not exactly described in the patients information

All rchived 136 tissues were obtained and pathologically confirmed from patients who underwent surgical resections between 2005 and 2006 at the Cancer Center of Sun Yat-sen University (Guangzhou, Guangdong, P. R. China)). The patients from whom the samples were derived underwent curative resection between 2005 and 2006. Tumor differentiation was characterized according to WHO classification, while the surgical pathologic stage was analyzed according to the TNM classification system of the International Union against Cancer. All samples were anonymously coded in accordance with local ethical guidelines.