Patients recruitment and analysis were terminated

There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Inclusion Criteria:

• ADPKD patients with normal renal function,
• Normotensive ADPKD patients

Exclusion Criteria:

• Patients with impaired kidney function,
• Atherosclerotic disorders,
• Diagnosis of hypertension, gout, diabetes,
• Using of insulin, thiazide, allopurinol or uricosuric drugs

Patients with early stage(preserved renal function) Autosomal dominant polycystic kidney disease (n = 91) from two academic medical center.We also excluded the patients with a previous diagnosis of hypertension, gout, diabetes, current use of oral antidiabetic medication, insulin, thiazide, allopurinol or uricosuric, or a fasting glucose level 126 mg/dl. In addition, the subjects with a history of smoking or current use of any anti-hypertensive medication and statins were excluded