The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease

Endothelial Dysfunction in Patients With Polycystic Kidney Disease

There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Inclusion Criteria:

• ADPKD patients with normal renal function,
• Normotensive ADPKD patients

Exclusion Criteria:

• Patients with impaired kidney function,
• Atherosclerotic disorders,
• Diagnosis of hypertension, gout, diabetes,
• Using of insulin, thiazide, allopurinol or uricosuric drugs