Effect of Early management on PAin and DEpression in patients with PancreatoBiliary Cancer, EPADE-PB

Purpose

To determine whether early palliative care integrated with usual oncologic care with automated symptom monitoring can improve depression and pain in patients with cancer

Inclusion Criteria:

• Ages Eligible for Study: 18 Years and older Genders Eligible for Study: Both Accepts Healthy Volunteers: No
• Pathologic confirmed locally advanced or metastatic pancreatic cancer or biliary tract cancer
• within 8 weeks after diagnosis
• cancer-related pain (Brief Pain Inventory [BPI] worst pain score >3), depression (Center for Epidemiological Studies-Depression Scale [CES-D] >16) or both
• Karnofsky Performance Rating Scale ≥50%

Exclusion Criteria:

• Opioid intolerance
• History of drug or alcohol abuse
• Impaired sensory or cognitive function
• Pregnant or lactating woman
• Women of child bearing potential not using a contraceptive method
• Sexually active fertile men not using effective birth control during medication of study drug and up to 6 months after completion of study drug if their partners are women of child-bearing potential