This is a single-center, open-lable, non-comparative, prospective, phase Ⅱ efficacy and safety study. Eligible patients are enrolled in a single group. The investigators propose to determine the efficacy and safety of low-dose metronomic chemotherapy with Etoposide/Capecitabine in Patients with Metastatic Breast Cancer Previously Treated with Anthracyclines and/or Taxanes.

Inclusion Criteria:

• female patients between 18 and 65 years old
• patients with metastatic breast cancer previousely treated with A/T
• able and willing to give consent to participate in the study

Exclusion Criteria:

• pregnant or lactating females
• other tumor history
• instable complication (e.g., myocardial infarction within 6 months,arrhythmia, unstable diabetes, hypercalcemia) or uncontrolled infection
• concurrent disease or condition that would make the patient inappropriate for study participation
• resist to participate in the study