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Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle.
Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle. Subjects will attend a 5 hour post-prandial study day. Subjects will keep food records 1 and 3 days prior to study visit, day of visit, and day after visit; food to be weighed using study provided dietary scale.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whey protein | Active Comparator | Complete whey protein. |
|
| Whey-CMP | Active Comparator | Complete whey protein missing the CMP (aka GMP) portion of the peptide. |
|
| Control | Placebo Comparator | Placebo preload control, matched for energy. |
|
| CMP (casinomacropeptide) | Active Comparator | Small peptide cleaved from complete whey protein. |
|
| MPI | Active Comparator | Complete milk protein. |
|
| CPI (casein) | Active Comparator | Preload containing casein. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whey | Other | Preload containing complete whey protein. |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Post-prandial satiety | Blood biochemical markers of appetite regulation. | 6 hours |
| Post-prandial satiety | Assessing biobehavioral aspects of appetite regulation through VAS. | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Extended satiety | Utilizing self reported food intake, looking for changes associated with the different proetin compositions of the shakes. | 48 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Britt Burton-Freeman, PhD, MS | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, Davis (Ragle Human Nutrition Research Center) | Davis | California | 95616 | United States |
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| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000067796 | Whey |
| D003568 | Cytidine Monophosphate |
| C110747 | cyclopropapyrroloindole |
| D002364 | Caseins |
| ID | Term |
|---|---|
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| Whey-CMP | Other | Preload containing complete whey protein which is missing the CMP/GMP portion of the protein. |
|
| Control | Other | Preload control matched for energy to the other 5 preloads. |
|
| CMP | Other | Preload containing the CMP (casinomacropeptide) portion cleaved from complete whey protein. |
|
|
| MPI | Other | Preload containing whole milk protein. |
|
|
| CPI | Other | Preload containing sodium caseinate. |
|
|
| D003611 |
| Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |
| D003597 | Cytosine Nucleotides |
| D011742 | Pyrimidine Nucleotides |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012265 | Ribonucleotides |
| D008894 | Milk Proteins |
| D000080224 | Animal Proteins, Dietary |
| D004044 | Dietary Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D010750 | Phosphoproteins |