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| Name | Class |
|---|---|
| Azienda Ospedaliero, Universitaria Ospedali Riuniti | OTHER |
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Aim of the study is to evaluate the effects, on microcirculation of septic patient, of three types of RBCs: 1- fresh standard RBCs (storage <10 days); 2-leukodepleted RBCs and 3-old standard RBCs (storage >15 days) respectively. Before and 1 hour after the transfusion, microcirculation is evaluated using Sidestream Dark Field Imaging (SDF) and Near InfraRed Spectroscopy (NIRS) with vascular occlusion test. We also monitor temperature, heart rate, mean blood pressure, hemochrome, blood gases, blood lactates and SOFA score.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fresh not-leukocyte-reduced RBCs | Active Comparator |
| |
| Fresh RBCs leukocyte-reduced | Active Comparator |
| |
| RBCs with storage longer than 15 days | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood transfusion | Biological | RBCs have been transfused in septic patient admitted in ICU |
|
| Measure | Description | Time Frame |
|---|---|---|
| Microcirculatory Flow Index (MFI) before and after blood transfusion. | Microcirculatory Flow Index detected in vivo by side-dark field imaging at sublingual microcirculation. It represents the quality of blood flow at microcirculatory level. This study wants to verify any of the considered different types of blood transfused can improve MFI. | One hour after the end of blood transfusion compared with before blood transfusion |
| Measure | Description | Time Frame |
|---|---|---|
| Perfused Vessel Density (PVD) | Perfused Vessel Density detected in vivo by side-dark field imaging at sublingual microcirculation. It represents the quantity of well perfused vessels at microcirculatory level. This study wants to verify any of the considered different types of blood transfused can improve PVD. | One hour after the end of blood transfusion compared with before blood transfusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Abele Donati, MD | Università Politecnica delle Marche | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University ICU, AOU Ospedali Riuniti | Torrette Di Ancona | Ancona | 60126 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25932999 | Derived | Damiani E, Adrario E, Luchetti MM, Scorcella C, Carsetti A, Mininno N, Pierantozzi S, Principi T, Strovegli D, Bencivenga R, Gabrielli A, Romano R, Pelaia P, Ince C, Donati A. Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis. PLoS One. 2015 May 1;10(5):e0122655. doi: 10.1371/journal.pone.0122655. eCollection 2015. | |
| 24528648 |
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| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| ID | Term |
|---|---|
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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| StO2 upslope | StO2 upslope is measured with Near InfraRed Spectroscopy at the tenar muscle. It represents the velocity of the recovery of the tissue oxygen saturation after a short period of ischemia of the hand, the Vascular Occlusion Test. | One hour after the end of blood transfusion compared with before blood transfusion |
| Arterial Blood Lactate | One hour after the end of blood transfusion compared with before blood transfusion |
| Arterial pH | One hour after the end of blood transfusion compared with before blood transfusion |
| SOFA score | One hour after the end of blood transfusion compared with before blood transfusion |
| Donati A, Damiani E, Luchetti M, Domizi R, Scorcella C, Carsetti A, Gabbanelli V, Carletti P, Bencivenga R, Vink H, Adrario E, Piagnerelli M, Gabrielli A, Pelaia P, Ince C. Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study. Crit Care. 2014 Feb 17;18(1):R33. doi: 10.1186/cc13730. |