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The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | fentanyl 1 mcg/kg before induction |
|
| D 0.5 group | Experimental | Dexmedetomidine 0.5 ug/kg + Propofol + Sevoflurane+ Vecuronium |
|
| D 1.0 group | Experimental | Dexmedetomidine 1.0 ug/kg + Propofol + Sevoflurane+ Vecuronium |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min | Drug | ECG monitoring for evaluation of QTc interval |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of QTc interval | T1- baseline, T2- to evaluate the effect of dexmedetomidine on QTc interval, T3- to evaluate QTc interval just before intubation, T4,5,6 - to evaluate QTc interval after intubation | T1 (at rest), T2 (5 min after dexmedetomidine infusion), T3 (just before intubation), T4(1 min after intubation), T5(2 min after intubation), T6(3min after intubation) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance hospital | Seoul | 120-752 | South Korea |
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| ID | Term |
|---|---|
| D007262 | Infusions, Intravenous |
| ID | Term |
|---|---|
| D061605 | Administration, Intravenous |
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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| D007263 |
| Infusions, Parenteral |