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Ezetimibe has become the treatment choice for patients with sitosterolemia. Ezetimibe is an inhibitor of cholesterol absorption from the gastrointestinal tract. The purpose of this study is to determine if ezetimibe improves whole body plant sterol and cholesterol homeostasis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ezetimibe | Experimental | Compare on and off ezetimibe |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ezetimibe | Drug | 10mg ezetimibe/day, at least 4 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma cholesterol level | Plasma cholesterol level will be assessed by GC | 8 months |
| Plasma sitosterol level | Plasma plant sterol assessment using GC | 8 months |
| Measure | Description | Time Frame |
|---|---|---|
| Cholesterol absorption | Use stable isotope technique to assess cholesterol absorption | 4 month |
| Cholesterol synthesis | Use of stable isotope to assess cholesterol synthesis. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Semone B Myrie, PhD | University of Manitoba | Principal Investigator |
| Peter J Jones, PhD | University of Manitoba | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Richardson Centre for Functional Foods and Nutraceuticals | Winnipeg | Manitoba | R3T 2N2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28625503 | Derived | Othman RA, Myrie SB, Mymin D, Roullet JB, DeBarber AE, Steiner RD, Jones PJH. Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe. J Pediatr. 2017 Sep;188:198-204.e1. doi: 10.1016/j.jpeds.2017.05.049. Epub 2017 Jun 16. | |
| 25444527 | Derived | Othman RA, Myrie SB, Mymin D, Merkens LS, Roullet JB, Steiner RD, Jones PJ. Ezetimibe reduces plant sterol accumulation and favorably increases platelet count in sitosterolemia. J Pediatr. 2015 Jan;166(1):125-31. doi: 10.1016/j.jpeds.2014.08.069. Epub 2014 Oct 16. |
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| ID | Term |
|---|---|
| C537345 | Sitosterolemia |
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| ID | Term |
|---|---|
| D000069438 | Ezetimibe |
| ID | Term |
|---|---|
| D001384 | Azetidines |
| D001385 | Azetines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| 4 months |