Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Convective therapies have been proposed for improving chronic dialysis patient outcomes, including intradialytic symptomatic hypotension.
To evaluate the frequency of sessions with intradialytic symptomatic hypotension in different types and doses of convective therapies compared with low-flux hemodialysis (HD), the investigators performed a multicentre, open-label, randomized controlled trial.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low-flux hemodialysis | No Intervention | ||
| online pre-dilution hemofiltration | Experimental |
| |
| online pre-dilution hemodiafiltration | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| online pre-dilution hemofiltration | Procedure | Online pre-dilution hemofiltration was performed with a synthetic high-flux membrane and an infusate/blood flow ratio of one |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intradialytic symptomatic hypotension | Intradialytic symptomatic hypotension was defined as a rapid symptomatic fall of the systolic blood pressure by at least 30 mmHg or that required nursing and/or medical intervention | all dialysis sessions, three per week, for 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Resistance to erythropoiesis-stimulating agents | Resistance to erythropoiesis-stimulating agents was measured as (EPO therapy in IU/week)/(Hb in g/dL*body wheight in kg) | Monthly for 2 years |
| Calcium-phosphate metabolism |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Francesco Locatelli, Professor | A. Manzoni Hospital, Lecco - Italy | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ospedale S.Marta S.Venera | Acireale (CT) | Italy | ||||
| Ospedale F. Miulli |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12953031 | Background | Bolasco P, Altieri P, Andrulli S, Basile C, Di Filippo S, Feriani M, Pedrini L, Santoro A, Zoccali C, Sau G, Locatelli F. Convection versus diffusion in dialysis: an Italian prospective multicentre study. Nephrol Dial Transplant. 2003 Aug;18 Suppl 7:vii50-4; discussion vii59-62. doi: 10.1093/ndt/gfg1080. | |
| 20813866 | Result |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| online pre-dilution hemodiafiltration | Procedure | Online pre-dilution hemodiafiltration was performed with a synthetic high-flux membrane with an infusate/blood flow ratio of 0.6 and a dialysate plus infusate rate of 700 ml/min. |
|
|
Outcome measures: phosphatemia, calcemia and PTH
| Monthly for 2 years |
| Beta2 microglobulin | Every six months for 2 years |
| Acquaviva delle Fonti |
| Italy |
| Ospedale Civile | Alghero | Italy |
| Ospedale regionale di Aosta | Aosta | Italy |
| Ospedale degli Infermi | Biella | Italy |
| Ospedale SS. Trinità ASL 8 | Cagliari | Italy |
| S. Michele Hospital | Cagliari | Italy |
| Ospedale Civile "P. Merlo" | La Maddalena | Italy |
| Alessandro Manzoni Hospital | Lecco | Italy |
| Ospedale "C. POMA" | Mantua | Italy |
| T. EVOLI | Melito di Porto Salvo | Italy |
| Ospedale dell'Angelo | Mestre | Italy |
| Policlinico Multimedica IRCCS | Milan | Italy |
| Federico II | Naples | Italy |
| Ospedale San Francesco | Nuoro | Italy |
| San Giovanni di Dio | Olbia | Italy |
| Ospedale Antonio Segni | Ozieri | Italy |
| Ospedale Maggiore | Parma | Italy |
| Fondazione Maugeri | Pavia | Italy |
| Ospedale " E. AGNELLI " | Pinerolo | Italy |
| Dipartimento territoriale ASL 8 | Quartu Sant'Elena | Italy |
| Ospedale S.Maria delle Croci | Ravenna | Italy |
| Azienda Ospedaliera "Bianchi Melacrino Morelli," | Reggio Calabria | Italy |
| Ospedale Bolognini | Seriate | Italy |
| Ospedale Agostino Landolfi | Solofra | Italy |
| Ospedale San Camillo | Sorgono | Italy |
| ASL 2 Olbia - P.O. "P. Dettori", | Tempio Pausania | Italy |
| Locatelli F, Altieri P, Andrulli S, Bolasco P, Sau G, Pedrini LA, Basile C, David S, Feriani M, Montagna G, Di Iorio BR, Memoli B, Cravero R, Battaglia G, Zoccali C. Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD. J Am Soc Nephrol. 2010 Oct;21(10):1798-807. doi: 10.1681/ASN.2010030280. Epub 2010 Sep 2. |
| 24557989 | Derived | Locatelli F, Altieri P, Andrulli S, Sau G, Bolasco P, Pedrini LA, Basile C, David S, Gazzanelli L, Tampieri G, Isola E, Marzolla O, Memoli B, Ganadu M, Reina E, Bertoli S, Ferrara R, Casu D, Logias F, Tarchini R, Mattana G, Passaghe M, Fundoni G, Villa G, Di Iorio BR, Pontoriero G, Zoccali C. Phosphate levels in patients treated with low-flux haemodialysis, pre-dilution haemofiltration and haemodiafiltration: post hoc analysis of a multicentre, randomized and controlled trial. Nephrol Dial Transplant. 2014 Jun;29(6):1239-46. doi: 10.1093/ndt/gfu031. Epub 2014 Feb 20. |
| ID | Term |
|---|---|
| D014511 | Uremia |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
Not provided
Not provided