Exercise in Breast Cancer Survivors

Exercise in Breast Cancer Survivors: Analysis of Angiogenic Profile

The investigators hypothesize that exercise in postmenopausal breast cancer survivors will result in an increase in the plasma concentrations of angiostatic factors and a decrease in the plasma concentrations of angiogenic factors. Exercise is expected to result in a circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer tumor, growth of microscopic residual disease after breast cancer resection, decreases rates of local-regional recurrence, decreases rates of distant recurrence, and increases survival.

Inclusion Criteria:

• > 18 years of age and < 65 years of age
• Female
• BMI > 25
• Weight < 350 pounds
• English as a primary language
• Postmenopausal
• Invasive ER-positive cancer on biopsy and subsequent definitive surgical therapy
• Received and Completed standard of care adjuvant therapy (Concurrent endocrine therapy acceptable)
• 6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at time of randomization

Exclusion Criteria:

• Recurrent breast cancer
• DCIS only (no invasive component)
• Taking a Beta Blocker or Verapamil
• Pregnant
• Wheelchair bound
• Unable to ambulate independently
• Concurrent uncontrolled medical or psychiatric disorder
• Open wound
• Stage IV breast cancer
• Progression of disease
• Bilateral mastectomies