The study was ultimately not funded by the sponsor. No subjects were enrolled.

The investigators are doing this study to find out if they can use electroencephalographic (EEG) recordings, which measure brain waves, to predict response to antidepressant treatments, as well as to distinguish patients who have depression from those who do not. In particular the investigators want to test the usefulness of a new type of analysis of EEG recordings called brain network activation or BNA. BNA allows to identify patterns of activation in brain networks and to track their changes over time.

For Patients with Major Depressive Disorder

Inclusion Criteria:

• • Male and female outpatients, aged 18-55 years

  • Subjects meeting full criteria for the diagnosis of current Major Depressive Disorder (MDD) without psychotic features, as determined by clinical evaluation and Mood Module of structured diagnostic interview (SCID), completed by the study clinician.
  • HAM-D17 score of 14 or higher
  • Able to provide informed consent
  • Right handed, normal (corrected) vision and normal hearing

Exclusion Criteria:

• • Other primary diagnoses including major depressive disorder with psychotic features, bipolar disorder, schizoaffective disorder, schizophrenia, dementia, attention deficit hyperactivity disorder (ADHD).

  • Substance use disorder (abuse or dependence with active use within the last 6 months).
  • Significant sensory deficits such as deafness or blindness.
  • Severe or unstable medical illness, including history of closed head injury resulting in loss of consciousness, seizure disorder; history of neurological disorders.
  • Pregnant or nursing females who are not using an accepted method of contraception (birth control pill, IUD, combination of barrier methods)
  • Clinically significant abnormal laboratory values or electrocardiogram For Healthy Controls

Inclusion Criteria:

• Males and females, aged 18-55 years
• Subjects who do not meet full criteria for any of the major psychiatric diagnosis including MDD, bipolar disorder, schizophrenia, substance abuse/dependence, attention deficit hyperactivity disorder (ADHD), as determined by clinical evaluation and structured diagnostic interview, completed by the study clinician.
• Right handed, normal (corrected) vision and normal hearing

Exclusion Criteria:

• Any current primary psychiatric, or medical condition determined to be clinically significant.
• Current use of psychotropics or any medication with clinically significant central nervous system effects.

For Patients with Major Depressive Disorder

• Subjects meeting full criteria for the diagnosis of current Major Depressive Disorder (MDD) without psychotic features, as determined by clinical evaluation and Mood Module of structured diagnostic interview (SCID), completed by the study clinician.

For Healthy controls

• Males and females, aged 18-55 years
• Subjects who do not meet full criteria for any of the major psychiatric diagnosis including MDD, bipolar disorder, schizophrenia, substance abuse/dependence, as determined by clinical evaluation and structured diagnostic interview, completed by the study clinician.