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| ID | Type | Description | Link |
|---|---|---|---|
| SPO 49798 | Other Grant/Funding Number | NIMH |
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| Name | Class |
|---|---|
| University of Chicago | OTHER |
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Anorexia Nervosa (AN) has the highest mortality rate compared to any other psychiatric disorder. The most promising treatment for adolescents with AN is family-based treatment (FBT). However, only 50% of patients receiving FBT fully remit at 12-month follow-up. Consequently, providing an alternative therapy early in the treatment course for those not responding to FBT may enhance overall outcome. This study aims to develop a new treatment - Intensive Family-Focused Treatment (IFT) - to improve outcomes in those adolescents, aged 12-18 years, who do not show an early response to FBT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Psychotherapy | Experimental | Family-Based Therapy (12 sessions) |
|
| Family-Based Therapy with Intensive Family-Focused Treatment | Experimental | The patient will receive 4 sessions of Family-Based therapy, and if the participant does not make adequate weight gain within this time period, will be assigned to Intensive Family-Focused Therapy (IFT). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Family-Based Therapy (FBT) | Behavioral | 12 sessions of FBT over the course of 6 months. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Full remission from AN (%MBW>95) | Weight restoration to at least 95% of Median body weight (calculated by height, weight, gender, and age) | End of Treatment (6 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in subscale scores of the EDE | Eating Disorder Examination subscale measures (weight concern, shape concern, dietary restraint) within 1 standard deviation of normative scores. | End of Treatment (6 months) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| James D Lock, MD, PhD | Stanford University | Principal Investigator |
| Daniel LeGrange, PhD | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94305 | United States | ||
| University of Chicago |
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| Label | URL |
|---|---|
| Related information | View source |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| D001068 | Feeding and Eating Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Family-Based Therapy with Intensive Family-Focused treatment |
| Behavioral |
FBT for 4 weeks then Intensive Family-Focused treatment (IFT) should the participant not make adequate weight progress within the time frame. |
|
| Chicago |
| Illinois |
| 60637 |
| United States |