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Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study to characterize the cellular and molecular mechanisms immune response to surgical trauma. Additionally, detailed information about patients' recovery profile will be recorded over a period of 6 weeks, with the eventual goal of linking immune responses to recovery profiles.
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| Measure | Description | Time Frame |
|---|---|---|
| Mass cytometry of immune signaling events | The primary molecular outcome is the fold change in phosphorylation of signaling proteins. | Blood samples for mass cytometry will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op. |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical Recovery Scale (SRS) | The surgical recovery scale is a validated questionnaire yielding a numerical score and assessing postoperative recovery. | Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks. |
| Western Ontario and McMaster Universities Arthritis Index (WOMAC) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing primary hip replacement.
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| Name | Affiliation | Role |
|---|---|---|
| Martin S Angst, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University Hospital | Stanford | California | 94305 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25253674 | Derived | Gaudilliere B, Fragiadakis GK, Bruggner RV, Nicolau M, Finck R, Tingle M, Silva J, Ganio EA, Yeh CG, Maloney WJ, Huddleston JI, Goodman SB, Davis MM, Bendall SC, Fantl WJ, Angst MS, Nolan GP. Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med. 2014 Sep 24;6(255):255ra131. doi: 10.1126/scitranslmed.3009701. |
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Whole blood
Western Ontario and McMaster Universities Arthritis Index is a validated questionnaires yielding a numerical score and assessing functional status and pain in patients suffering from osteoarthritis of the hip. |
| Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks. |
| Plasma cytokines | The plasma concentration of plasma cytokines and chemokines will be measured with aid of a large protein array. | Blood samples will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op. |